MITF Polyclonal Antibody, Invitrogen™

Transcription factor for tyrosinase and tyrosinase-related protein 1. Binds to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3') found in the tyrosinase promoter. Plays a critical role in the differentiation of various cell types as neural crest-derived melanocytes, mast cells, osteoclasts and optic cup-derived retinal pigmant epithelium. This protein is a transcription factor that contains both basic helix-loop-helix and leucine zipper structural features. It regulates the differentiation and development of melanocytes retinal pigment epithelium and is also responsible for pigment cell specific transcription of the melanogenesis enzyme genes. Heterozygous mutations in the this gene cause auditory-pigmentary syndromes, such as Waardenburg syndrom type 2 and Tietz syndrome. Alternateively spliced transcript variants encoding different isoforms have been identified.
Host Species: Chicken
Cross Reactivity: Human
Isotype: IgY
Immunogen: Synthetic peptide corresponding to human Microphthalmia-associated transcription factor.
Formulation: 50μg purified antibody in PBS and no preservative
Synonyms: MI, WS2A, bHLHe32
Uniprot Accession: O75030
Entrez GeneID: 4286
Gene Symbol: MITF
PA1-27613 detects MITF from human samples. PA1-27613 may be successfully used in Western blot applications. By Western blot, this antibody has only been tested on fusion protein. The immunogen is a synthetic peptide corresponding to human Microphthalmia-associated transcription factor. Store at 4ºC short term. For extended storage aliquot and store at -20ºC or below. Avoid freeze-thaw cycles.