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IRS-1 Mouse, Unlabeled, Clone: 6, BD

Mouse Monoclonal Antibody

241.00€ - 416.80€

Especificaciones

Antígeno IRS-1
Isotipo IgG1
Inmunógeno Rat IRS-1 aa. 1131-1234
Formulación Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Conjugado Unconjugated
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Productos 2
Código de producto Marca Cantidad. Precio Cantidad y disponibilidad  
Código de producto Marca Cantidad. Precio Cantidad y disponibilidad  
15815919 Ver documentos BD Biosciences
611394
50μg 241.00€
cada uno Ver productos alternativos
Ahorre hasta 
»
Fecha estimada de envío
11-10-2019
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15825919 Ver documentos BD Biosciences
611395
150μg 416.80€
cada uno Ver productos alternativos
Ahorre hasta 
»
Fecha estimada de envío
11-10-2019
Añadir a la cesta
 
Descripción

Descripción

The IRS (Insulin receptor substrate) proteins IRS-1, IRS-2, IRS-3, and IRS-4 are major substrates of the insulin receptor tyrosine kinase and the insulin-like growth factor-1 receptor. IRS proteins contain an N-terminal pleckstrin homology (PH) domain, an ATP-binding domain, and multiple tyrosine phosphorylation sites in the C-terminus. Following insulin receptor ligation, IRS-1 binds to the juxtamembrane region of the receptor and is tyrosine phosphorylated. This facilitates its interaction with SH2 domain-containing signaling proteins, such as PI3 kinase, fyn, Grb2, and PTP1D. Phosphorylation dramatically reduces the affinity of IRS-1 for the insulin receptor, indicating that dissociation from the receptor and subsequent subcellular translocation are important to IRS-1 function in the pleiotropic effects induced by insulin. In support of this, IRS-1-null mice are viable, but exhibit growth retardation and abnormal glucose metabolism. In cases of reduced IRS-1 expression, certain IRS-1 functions can be assumed by the related IRS-2 protein, while other activities linked to IRS-1 are inhibited. Thus, IRS-1 is an essential component of insulin induced signal transduction.

Immunofluorescence, Western Blotting

Especificaciones

Especificaciones

IRS-1
Rat IRS-1 aa. 1131-1234
Unconjugated
Cell Biology
Murine
Affinity Purified
Monoclonal
Store undiluted at -20°C.
IgG1
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Primary
Western Blot
RUO
6
250μg/mL

For Research Use Only.