anti-ICOS/CD278 PE-Cy7™, Clone: ISA-3, Invitrogen™

CD278 belongs to the CD28 and CTLA-4 cell-surface receptor family and is highly expressed in activated T-cells. It is essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. It enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells.
Host Species: Mouse
Cross Reactivity: Human
Isotype: IgG1
Clone: ISA-3
Immunogen: Human ICOS
Formulation: 25 Tests Purified Antibody in proprietary buffer, with 0.09% sodium azide
Synonyms: AILIM, CD278, CVID1, activation-inducible lymphocyte immunomediatory molecule, inducible T-cell costimulator, inducible costimulator
Uniprot Accession: Q9Y6W8
Entrez GeneID: 29851
Gene Symbol: ICOS
This product detects ICOS/CD278 in Human samples. This product has been successfully used in Flow Cytometry procedures. The immunogen is Human ICOS.