anti-HLA-DR Qdot™ 800, Clone: Tü36, Invitrogen™

HLA-DRA is one of the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha and a beta chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5.
Host Species: Mouse
Cross Reactivity: Human
Isotype: IgG2b
Clone: Tü36
Immunogen: Human HLA-DR
Formulation: 100μL Purified Antibody in 0.05M borate, with 1M betaine and 0.05% sodium azide; pH8.3
Synonyms: DASS-397D15.1, FLJ51114, HLA-DRA1,mLRW, HLA class II histocompatibility antigen, DR alpha chain, MHC cell surface glycoprotein, MHC class II antigen DRA, histocompatibility antigen HLA-DR alpha
Uniprot Accession: P01903
Entrez GeneID: 3122
Gene Symbol: HLA-DRA
This product detects HLA-DR in Human samples. This product has been successfully used in Flow Cytometry procedures. The immunogen is Human HLA-DR.