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GTP cyclohydrolase 1, Rabbit, Purified MaxPab™ Polyclonal Antibody, Abnova™
Rabbit polyclonal antibody raised against a full-length human GCH1 protein.
Marca: Abnova H00002643-D01P.100ug
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Descripción
This gene encodes a member of the GTP cyclohydrolase family. The encoded protein is the first and rate-limiting enzyme in tetrahydrobiopterin (BH4) biosynthesis, catalyzing the conversion of GTP into 7,8-dihydroneopterin triphosphate. BH4 is an essential cofactor required by aromatic amino acid hydroxylases as well as nitric oxide synthases. Mutations in this gene are associated with malignant hyperphenylalaninemia and dopa-responsive dystonia. Several alternatively spliced transcript variants encoding different isoforms have been described; however, not all variants give rise to a functional enzyme. [provided by RefSeq
Sequence: MEKGPVRAPAEKPRGARCSNGFPERDPPRPGPSRPAEKPPRPEAKSAQPADGWKGERPRSEEDNELNLPNLAAAYSSILSSLGENPQRQGLLKTPWRAASAMQFFTKGYQETISDVLNDAIFDEDHDEMVIVKDIDMFSMCEHHLVPFVGKVHIGYLPNKQVLGLSKLARIVEIYSRRLQVQERLTKQIAVAITEALRPAGVGVVVEATHMCMVMRGVQKMNSKTVTSTMLGVFREDPKTREEFLTLIRSEspecificaciones
| GTP cyclohydrolase 1 | |
| Polyclonal | |
| Rabbit polyclonal antibody raised against a full-length human GCH1 protein. | |
| GCH1 | |
| DYT14/DYT5/GCH/GTP-CH-1/GTPCH1 | |
| Rabbit | |
| Affinity Purified | |
| RUO | |
| 2643 | |
| Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. | |
| IgG |
| Immunofluorescence, Western Blot | |
| Unconjugated | |
| PBS with no preservative; pH 7.4 | |
| NM_000161.2 | |
| GCH1 | |
| GCH1 (NP_000152.1, 1 a.a. ∼ 250 a.a) full-length human protein. | |
| 100 μg | |
| Primary | |
| Human | |
| Antibody |
Título del producto
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