Invitrogen™ Epstein Barr Virus Nuclear Antigen 1 Polyclonal Antibody, HRP

Descripción

The PA1-7498 antibody reacts with Epstein-Barr virus EBNA-1. PA1-7498 has been successfully used in ELISA applications. The PA1-7498 antibody was raised against Recombinant EBV EBNA-1. Note: Sodium azide is a potent inhibitor of peroxidase.

Epstein-Barr virus (EBV) is a human herpes virus, which is associated with conditions such as Hodgkin's disease and Burkitt's Lymphoma and is the causative agent in mononucleosis in adolescents. EBV latently infects B lymphocytes. Infected B cells express EBV nuclear antigens and latent proteins LMP1, LMP2A and LMP2B. LMP2A forms aggregates in the plasma membranes of B lymphocytes, where it functions as a negative regulator of the Src and Syk protein tyrosine kinases. Studies show that LMP2A blocks B-cell receptor (BCR) signal transduction in EBV immortalized B cells in vitro and may play an important role in maintaining a latent EBV infection within the peripheral blood B cells of infected individuals.EBNA-1 is the only viral protein consistently expressed in all malignancies associated with EBV.