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eIF-5a Mouse, Unlabeled, Clone: 26, BD
Mouse Monoclonal Antibody
Marca: BD Biosciences 611976
180.33 EUR hasta el 2025-12-31
Use el código promocional "25339" para aplicar la oferta.
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Descripción
Initiation of eukaryotic translation involves a series of reactions mediated by multiple eukaryotic initiation factors (eIFs). However, one member of this family, eIF-5a, may have multiple protein functions. eIF-5a was originally identified as an initiation factor due to its binding of ribosomes, and its stimulation of methionyl-puromycin. Regulation of initiation may not be the major function of eIF-5a, since it functions as a targeting protein for the HIV protein, Rev, and the T-cell leukemia virus type 1 protein, Rex. In Xenopus oocytes, eIF-5a interacts with the nucleoporins Nup214, Nup153, Nup98, and Nup62, and is required for Rev-NES interaction with exportin1. These interactions may be involved with eIF-5a nuclear export of Rev protein, and eIF-5a requirement for Rev-mediated viral RNA export. eIF-5a is ubiquitously expressed, and is the only known eukaryotic protein that contains the post-translationally formed hypusine residue. Modification of eIF-5a with hypusine is coupled to cell proliferation, and disruption of this residue in yeast eIF-5a is lethal. Thus, eIF-5a may be an important nuclear transport protein with conserved function in many species.
Host Species: Mouse
Clone: 26
Isotype: IgG1
Species Reactivity [for Features Main]: Human
Immunogen: Human eIF-5a aa. 58-154
Bioimaging, Immunofluorescence, Western Blotting
Especificaciones
| eIF-5a | |
| Monoclonal | |
| 250μg/mL | |
| Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. | |
| Human eIF-5a aa. 58-154 | |
| 50 μg | |
| Cell Biology | |
| Canine, Chicken, Human, Mouse, Rat | |
| IgG1 |
| Western Blot | |
| 26 | |
| Unconjugated | |
| Mouse | |
| Affinity Purified | |
| RUO | |
| Primary | |
| Store undiluted at -20°C. |
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Título del producto
eIF-5a Mouse, Unlabeled, Clone: 26, BD > 50μg; Unlabeled
For Research Use Only.
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