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E-Cadherin Mouse, Unlabeled, Clone: 36/E-CADHERIN, BD

Mouse Monoclonal Antibody

459.00€ - 735.00€

Especificaciones

Antígeno E-Cadherin
Clon 36/E-CADHERIN
Concentración 250μg/mL
Aplicaciones Western Blot
Clasificación Monoclonal
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Productos 2
Código de producto Marca Cantidad Precio Cantidad y disponibilidad  
Código de producto Marca Cantidad Precio Cantidad y disponibilidad  
15865309
Ver documentos Detalles de la promoción
BD Biosciences
610181
50 μg
459.00€
1 set
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Fecha estimada de envío: 14-06-2024
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15875309
Ver documentos Detalles de la promoción
BD Biosciences
610182
150 μg
735.00€
1 set
Ver productos alternativos
Ahorre hasta 
»
Fecha estimada de envío: 13-06-2024
para ver el stock
Por favor, para comprar este producto. ¿No tiene usuario web? Regístrese hoy mismo.
Descripción

Descripción

E-Cadherin is a 120-kDa transmembrane glycoprotein that is localized in the adherens junctions of epithelial cells. There it interacts with the cytoskeleton through the associated cytoplasmic catenin proteins. In addition to being a calcium-dependent adhesion molecule, E-Cadherin is also a critical regulator of epithelial junction formation. Its association with catenins is necessary for cell-cell adhesion. These E-cadherin/catenin complexes associate with cortical actin bundles at both the zonula adherens and the lateral adhesion plaques. Tyrosine phosphorylation can disrupt these complexes, leading to changes in cell adhesion properties. E-Cadherin expression is often down-regulated in highly invasive, poorly differentiated carcinomas. Increased expression of E-Cadherin in these cells reduces invasiveness. Thus, loss of expression or function of E-Cadherin appears to be an important step in tumorigenic progression. The 36/E-Cadherin monoclonal antibody recognizes the cytoplasmic domain of E-Cadherin, regardless of phosphorylation status. The peptide immunogen was generated from human E-Cadherin aa. 735-883.

Note: Investigators are advised that this antibody has some degree of cross-reactivity to P-Cadherin.

Especificaciones

Especificaciones

E-Cadherin
250μg/mL
Monoclonal
Mouse
Cell Biology
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
IgG2a κ
Affinity Purified
CD324; CDH1; CADH1; Cadherin-1; ECAD; CDHE; Arc-1; LCAM; UVO; Uvomorulin
36/E-CADHERIN
Western Blot
Unconjugated
RUO
Canine, Human, Mouse, Rat
IgG2a, κ
Primary
Store undiluted at -20°C.
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Documentos

Documentos

Product Certifications

For Research Use Only.