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CDC42 Mouse, Unlabeled, Clone: 44, BD
Mouse Monoclonal Antibody
179.00€ - 340.00€
Especificaciones
| Antígeno | CDC42 |
|---|---|
| Clon | 44 |
| Concentración | 250μg/mL |
| Aplicaciones | Western Blot |
| Clasificación | Monoclonal |
| Código de producto | Marca | Cantidad | Precio | Cantidad y disponibilidad | |||||
|---|---|---|---|---|---|---|---|---|---|
| Código de producto | Marca | Cantidad | Precio | Cantidad y disponibilidad | |||||
|
15865709
|
BD Biosciences
610928 |
50 μg |
179.00€
1 set |
Por favor, inicie sesión para comprar este producto. ¿No tiene usuario web? Regístrese hoy mismo. | |||||
|
15875709
|
BD Biosciences
610929 |
150 μg |
340.00€
1 set |
Por favor, inicie sesión para comprar este producto. ¿No tiene usuario web? Regístrese hoy mismo. | |||||
Descripción
Rho family members are small GTP binding proteins that serve as molecular switches for a number of biological processes. They cycle between active GTP-bound and inactive GDP-bound states. CDC42 is a Rho family protein that was identified in membranes of human platelets and placenta. It is the homologue of CDC42Sc, which regulates initiation of bud-site assembly in Saccharomyces cerevisiae. CDC42 regulates the function of the mammalian actin cytoskeleton, allowing for efficient cytokinesis and cell morphogenesis. CDC42 and Rac1, a Ras-related GTPase, activate MEKK1, a JNK kinase kinase, which leads to the activation of several downstream components of the MAP kinase cascade leading to activation of PAK65, a CDC42- and Rac-binding protein. PAK65 interacts with CDC42/Rac1, mediates their interaction with MEKK1, and enhances MEKK1 catalytic activity. Chronic activation of CDC42 has been shown to induce malignant cellular transformation. Due to sequence homology among various small GTPase family members, potential cross-reactivity could be observed with this antibody. BD Pharmingen has not performed such cross-reactivity testing.
Immunofluorescence, Western Blotting
Especificaciones
| CDC42 | |
| 250μg/mL | |
| Monoclonal | |
| Mouse | |
| Cell Biology | |
| Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. | |
| IgG1 | |
| Affinity Purified |
| 44 | |
| Western Blot | |
| Unconjugated | |
| RUO | |
| Canine, Human, Mouse, Rat | |
| Human CDC42 aa. 1-191 | |
| Primary | |
| Store undiluted at -20°C. |
For Research Use Only.
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