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CD58 (LFA-3) Mouse anti-Human, PE, Clone: L306.4, BD
Mouse Monoclonal Antibody
Marca: BD Biosciences 340295
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Descripción
CD58 (Anti-LFA-3), clone L306.4, is derived from hybridization of mouse Sp2/0 myeloma cells with spleen cells from C3H/HeN mice immunized with Lc-LFA-3 mouse L-cell transfectant.
CD58 (Anti-LFA-3) recognizes a 40 to 65-kdalton cell-surface glycoprotein that is a member of the immunoglobulin superfamily. The CD58 antigen, known as the lymphocyte function–associated antigen-3 (LFA-3), mediates cellular adhesion and participates in signal transduction when it binds to its ligand, the CD2 antigen. Cellular interactions regulated by the CD58/CD2 antigens are involved in the antigen-independent adhesion pathway and cytotoxic T lymphocyte (CTL) activity. The CD58 antigen has two isoforms. One isoform is anchored in the cell membrane by a glycophosphatidyl inositol tail, while the other has a transmembrane hydrophobic segment and a cytoplasmic segment composed of 12 amino acids.
Especificaciones
| CD58 | |
| Monoclonal | |
| PE | |
| Mouse | |
| 50 Tests | |
| Immunology | |
| Human | |
| IgG2a κ |
| Flow Cytometry | |
| L306.4 | |
| Phosphate buffered saline with gelatin and 0.1% sodium azide. | |
| Lc-LFA-3 mouse L-cell transfectant | |
| RUO | |
| Primary | |
| Store vials at 2-8°C. Conjugated forms should not be frozen and should be protected from prolonged exposure to light. Each reagent is stable for the period shown on the bottle label when stored as directed. |
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