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CD294 (CRTH2) Rat anti-Human, PE, Clone: BM16, BD
Rat Monoclonal Antibody
Marca: BD Biosciences 563665
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Descripción
The BM16 monoclonal antibody specifically binds to CD294. CD294 is encoded by PTGDR2 (Prostaglandin D2 receptor 2) and is also known as CRTH2 (chemoattractant receptor-homologous molecule expressed on Th2 cells), GPR44 (G protein-coupled receptor 44), DL1R, and DP2. CD294 is a member of the G protein-coupled leukocyte chemoattractant receptor family. CD294 is expressed on Th2 cells and type-2 innate lymphoid cells (ILC2), but not Th1 type cells. CD294 is detectable on CD4+ T cells in fresh PBMC but not on B cells and NK cells. CD294 is also expressed on peripheral blood basophils and eosinophils, suggesting its involvement allergic reactions. Phenotypic analysis of CD4+ T cells expressing CRTH2 demonstrated that they were also CD45RA-negative and CD45RO+ and CD25+. These cells produce Th2- but little or no Th1-type cytokines upon stimulation with PMA and Ionomycin.
Especificaciones
| CD294 (CRTH2) | |
| Monoclonal | |
| PE | |
| Rat | |
| Affinity Purified | |
| RUO | |
| Human | |
| IgG2a κ |
| Flow Cytometry | |
| BM16 | |
| CRTH2; PTGDR2 ; Prostaglandin D2 receptor 2; DL1R; DP2; GPR44 | |
| Human CRTH2 Transfected Cell Line | |
| 100 Tests | |
| Primary | |
| Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. |
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