CD206 Mouse anti-Human, Unlabeled, Clone: 19.2, BD

Reacts with the macrophage mannose receptor (MR), a membrane glycoprotein of approximately 162kDa which binds to glycoconjugates containing mannose, fucose, or N-acetylglucosamine. These carbohydrates are present on the surface of many microorganisms and enable the macrophage to bind to microorganisms through the MR and internalize them during the process of phagocytosis. Mannose receptors are expressed on human macrophages and cultured dendric cells. They are not detected on resting moncytes. Mannose receptor expression is upregulated on PBMC following 3 day incubation with GM-CSF. This antibody is routinely tested by flow cytometric analysis. Other applications were tested at BD Biosciences Pharmingen during antibody development only or reported in the literature.