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CD178 Mouse anti-Human, Unlabeled, Clone: NOK-2, BD
Mouse Monoclonal Antibody
Marca: BD Biosciences 556376
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Descripción
Fas (APO-1, CD95) is a 45kDa cell surface protein that mediates apoptosis when cross-linked with agonistic anti-Fas antibodies or Fas ligand (FasL). Fas belongs to the TNF (tumor necrosis factor)/NGF (nerve growth factor) receptor family, and is expressed in various tissue and cells including the thymus, liver, ovary, and lung. FasL is a 40kDa TNF family membrane protein that induces apoptosis by binding to Fas, its cell-surface receptor. FasL is expressed on activated T and NK cells. Both Fas and FasL are thought to play an important role in the apoptotic processes that take place during T cell development. NOK-2 recognizes human FasL. It recognizes both the membrane bound (FasL) and soluble (sFasL) forms. L5178Y mouse T lymphoma cells expressing recombinant human FasL were used as immunogen. FasL and sFasL migrate at reduced molecular weights of 40 and 26kDa, respectively. However, the molecular weights observed in a particular sample may vary according to FasL and sFasL glycosylation and breakdown patterns as described in Tanaka et al.
Especificaciones
| CD178 | |
| Monoclonal | |
| 0.5mg/mL | |
| Fas Ligand, CD95 Ligand | |
| Mouse | |
| Affinity Purified | |
| RUO | |
| Primary | |
| Store undiluted at 4°C |
| Immunoprecipitation | |
| NOK-2 | |
| Unconjugated | |
| Aqueous buffered solution containing ≤0.09% sodium azide. | |
| L51788Y Mouse T Lymphoma Cells Expressing Recombinant Human FasL | |
| 0.1 mg | |
| Immunology | |
| Human | |
| IgG2a |
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Título del producto
For Research Use Only.
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