VE-cadherin/CD144 Polyclonal Antibody, Invitrogen™

This gene is a classical cadherin from the cadherin superfamily and is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Functioning as a classic cadherin by imparting to cells the ability to adhere in a homophilic manner, the protein may play an important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. An alternative splice variant has been described but its full length sequence has not been determined.
Host Species: Rabbit
Cross Reactivity: Bovine, Human, Mouse, Rat
Isotype: IgG
Immunogen: Recombinant protein fragments corresponding to amio acids 1-258 of VE-cadherin.
Formulation: 100μg purified antibody (1mg/mL) in PBS and no preservative
Synonyms: Cadherin-5, Vascular endothelial cadherin, VE-cadherin, 7B4 antigen, CD144 antigen, CDH5
Uniprot Accession: P33151, P55284, Q6URK6
Entrez GeneID: 1003, 12562, 307618, 414735
Gene Symbol: CDH5
This antibody does not cross react with N-cadherin, which is also expressed by endothelial cells. It has also been reported to block adhesive properties of VE-cadherin. For FACS analysis, use 10ul of the suggested working dilution to label 1x10^6 cells in 100ul.