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Beclin Mouse, Unlabeled, Clone: 20, BD

Mouse Monoclonal Antibody

343.00€ - 565.00€

Especificaciones

Antígeno Beclin
Clon 20
Concentración 250μg/mL
Aplicaciones Western Blot
Clasificación Monoclonal
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Productos 2
Código de producto Marca Cantidad Precio Cantidad y disponibilidad  
Código de producto Marca Cantidad Precio Cantidad y disponibilidad  
15826099
Ver documentos Detalles de la promoción
BD Biosciences
612112
50 μg
343.00€
1 set
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Fecha estimada de envío: 23-04-2024
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15836099
Ver documentos Detalles de la promoción
BD Biosciences
612113
150 μg
565.00€
1 set
Ver productos alternativos
Ahorre hasta 
»
Fecha estimada de envío: 23-04-2024
para ver el stock
Por favor, para comprar este producto. ¿No tiene usuario web? Regístrese hoy mismo.
Descripción

Descripción

Autophagy is the bulk degradation of cellular proteins through the autophagosomic-lysosomal pathway. This process is important for normal cell growth, and may be disrupted in tumor cells. Beclin is a Bcl-2 binding protein that is homologous to the yeast autophagy gene, apg6/vps30. The structure of beclin includes a Bcl-2 binding coiled-coil region, and a leucine-rich nuclear export signal (NES). Beclin protein colocalizes with intracytoplasmic organelles and nuclei in normal COS7 and MCF7 cells. However, inhibition of CRM1-dependent nuclear export leads to beclin localization primarily in the nucleus. Mutation of the NES domain of beclin also prevents nuclear export, as well as suppresses beclin-mediated nutrient deprivation-induced autophagy. In addition, these beclin mutants can not inhibit in vitro clonigenicity and in vivo tumorigenicity of MCF7 cells. Beclin interaction with Bcl-2 may be involved with host viral defense, since overexpression of beclin inhibits Sindbis virus replication and expression of beclin lacking the Bcl-2 binding domain has no antiviral effects. Thus, beclin may be an important component of complexes involved in autophagy.

Western Blotting

Especificaciones

Especificaciones

Beclin
250μg/mL
Monoclonal
Mouse
Cell Biology
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
IgG2a
Affinity Purified
20
Western Blot
Unconjugated
RUO
Canine, Chicken, Human, Mouse, Rat
Human Beclin aa. 171-291
Primary
Store undiluted at -20°C.
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Documentos

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For Research Use Only.