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Invitrogen™ Angiopoietin 2 Polyclonal Antibody

Descripción
This antibody is specific for mouse Angiopoietin-2 (mAng-2). Partial cross-reactivity is observed with human Angiopoietin-1. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
ANG-2 binds to the endothelial cell specific receptor Tie-2, but, in contrast to ANG-1, does not induce tyrosine phosphorylation. Consequently, ANG-2 modulates ANG-1 activation of Tie-2 and, depending on the physiological and biochemical environment, can act either as an agonist or antagonist of Tie-2 induced angiogenesis. The signaling interactions of ANG-1, ANG-2 and Tie-2, along with less characterized ANG-3 and ANG-4, are required for embryonic and adult angiogenesis. Physiologically, ANG-1 and ANG-2 are associated with sprouting, tube formation, and structural integrity of newly formed blood vessels. Mature human ANG-2 is a secreted protein containing 480 amino acid residues. ANG-2 is composed of an alpha-helix-rich coiled coil N-terminal domain and fibrinogen-like C-terminal domain. ANG-2 exists predominantly in the form of a disulfide-linked dimer.
Especificaciones
Especificaciones
| Antígeno | Angiopoietin 2 |
| Aplicaciones | Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot |
| Clasificación | Polyclonal |
| Concentración | 80 mg/mL |
| Conjugado | Unconjugated |
| Formulación | PBS with 0.1% sodium azide; pH 7.2 |
| génica | ANGPT2 |
| N.º de referencia del gen | O15123, O35608 |
| Alias de gen | AGPT2; Ang2; Ang-2; angiopoietin 2; angiopoietin-2; angiopoietin-2a; angiopoietin-2B; ANGPT2; endothelial growth factor; Tie2-ligand |
| Símbolos de los genes | ANGPT2 |
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Título del producto
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