Invitrogen™ ADAM15 Polyclonal Antibody

Descripción

Positive Samples: Mouse heart, Mouse kidney, Mouse brain; Cellular Location: Cell junction, Cell projection, Cytoplasmic vesicle, Endomembrane system, Single-pass type I membrane protein, acrosome, adherens junction, cilium, flagellum, secretory vesicle Immunogen sequence: QPAAPLCLQT ANTRGNAFGS CGRNPSGSYV SCTPRDAICG QLQCQTGRTQ PLLGSIRDLL WETIDVNGTE LNCSWVHLDL GSDVAQPLLT LPGTACGPGL VCIDHRCQRV DLLGAQECRS KCHGHGVCDS NRHCYCEEGW APPDCTTQLK ATSSLTTGLL L.

The protein encoded by this gene is a member of the ADAM (a disintegrin and metalloproteinase) protein family. ADAM family members are type I transmembrane glycoproteins known to be involved in cell adhesion and proteolytic ectodomain processing of cytokines and adhesion molecules. This protein contains multiple functional domains including a zinc-binding metalloprotease domain, a disintegrin-like domain, as well as a EGF-like domain. Through its disintegrin-like domain, this protein specifically interacts with the integrin beta chain, beta 3. It also interacts with Src family protein-tyrosine kinases in a phosphorylation-dependent manner, suggesting that this protein may function in cell-cell adhesion as well as in cellular signaling. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed.