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ABL1 (phospho Y412) Rabbit anti-Human, Mouse, Rabbit, Polyclonal , Abnova™
Descripción
The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9;22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1. The ABL1 gene is expressed as either a 6- or 7-kb mRNA transcript, with alternatively spliced first exons spliced to the common exons 2-11. [provided by RefSeq]
Especificaciones
Especificaciones
| Antígeno | ABL1 (phospho Y412) |
| Aplicaciones | Immunofluorescence, Immunohistochemistry (PFA fixed) |
| Clasificación | Polyclonal |
| Conjugado | Unconjugated |
| Descripción | Rabbit polyclonal antibody raised against synthetic phosphopeptide of human ABL1. |
| Dilución | Immunofluorescence (1:100-1:200) Immunohistochemistry (1:50-1:100) The optimal working dilution should be determined by the end user. |
| Formulación | In PBS (without Mg2+ and Ca2+), 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide) |
| Alias de gen | ABL/JTK7/bcr/abl/c-ABL/p150/v-abl |
| Símbolos de los genes | ABL1 |
| Especie del huésped | Rabbit |
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