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Invitrogen™ 53BP2 Polyclonal Antibody
Rabbit Polyclonal Antibody
Marca: Invitrogen™ PA554468
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Descripción
Immunogen sequence: PQPSKDTLLP PFRKPQTVAA SSIYSMYTQQ QAPGKNFQQA VQSALTKTHT RGPHFSSVYG KPVIAAAQNQ QQHPENIYSN SQGKPGSPEP ETEPVSSVQE NHENERI Highest antigen sequence identity to the following orthologs: Mouse - 91%, Rat - 90%.
Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions. Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of APPBP1 to conjugate NEDD8 to CUL1, and thereby decreases APPBP1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42.
Especificaciones
| 53BP2 | |
| Polyclonal | |
| Unconjugated | |
| TP53BP2 | |
| 53BP2; Apoptosis-stimulating of p53 protein 2; apoptosis-stimulating protein of p53, 2; ASPP2; BBP; Bcl2-binding protein; P PPP1R13A; P53BP2; PPP1R13A; Renal carcinoma antigen NY-REN-51; TP53BP2; transformation related protein 53 binding protein 2; Trp53bp2; tumor protein p53 binding protein 2; tumor protein p53 binding protein, 2; tumor suppressor p53-binding protein 2 | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 7159 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
| Immunohistochemistry (Paraffin), Immunocytochemistry | |
| 0.1 mg/mL | |
| PBS with 40% glycerol and 0.02% sodium azide; pH 7.2 | |
| Q13625 | |
| TP53BP2 | |
| Recombinant protein corresponding to Human 53BP2. Recombinant protein control fragment (Product #RP-92050). | |
| 100 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG |
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