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Invitrogen™ 53BP1 Polyclonal Antibody
Rabbit Polyclonal Antibody
Marca: Invitrogen™ PA116565
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Descripción
Human has been tested in WB, IHC-P and ICC/IF, mouse and goat have only been tested in ICC/IF. Suggested positive control: U205, 293T, MO59K cell lysates and MEF lysates. Predicted cross-reactivity based on sequence identity: Chimpanzee/Gorilla/Orangutan (96%), Gibbon (94%), Marmoset (92%), Feline/Porcine/Rabbit/Sheep (90%).
53BP1 (P53-binding protein 1) plays a critical role in tumor suppression and is a putative substrate of ATM kinase. Upon DNA damage, 53BP1 is phosphorylated and localizes to the presumptive sites of damage, specifically, double-strand breaks. 53BP1 may have a role in checkpoint signaling during mitosis, enhances TP53-mediated transcriptional activation, and participates in DNA repair by maintaining genomic stability.
Especificaciones
| 53BP1 | |
| Polyclonal | |
| Unconjugated | |
| TP53BP1 | |
| 53BP1; FLJ41424; m53BP1; MGC138366; murine p53-binding protein; p202; p53-binding protein 1; p53BP1; TDRD30; TP53; TP53-binding protein 1; Tp53bp1; transformation related protein 53 binding protein 1; transformation related protein 53 binding-protein 1; Trp53bp1; tumor protein 53-binding protein, 1; tumor protein p53 binding protein 1; tumor protein p53-binding protein, 1; tumor suppressor p53-binding protein 1 | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 100358189, 100520655, 102182833, 27223, 296099, 478274, 509111, 7158 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
| ChIP Assay, Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry, Western Blot | |
| 1 mg/mL | |
| PBS with 0.02% sodium azide | |
| P70399, Q12888 | |
| TP53BP1, Trp53bp1 | |
| Partial synthetic peptide made to an internal portion of human 53BP1 (between amino acids 350-400). | |
| 100 μL | |
| Primary | |
| Human, Mouse, Rat, Canine, Rabbit, Monkey, Bovine, Pig, Fish, Rodent, Goat, Goat | |
| Antibody | |
| IgG |
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