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H3COHNBrFNNONH3C

CAS RN 443913-73-3

IUPAC Nombre: N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-amine
Sinónimos: vandetanib zactima C22H24BrFN4O2 vande-tanib
Peso molecular (g/mol): 475.36
Fórmula molecular: C22H24BrFN4O2
InChi Key: UHTHHESEBZOYNR-UHFFFAOYSA-N
SMILES: COC1=C(OCC2CCN(C)CC2)C=C2N=CN=C(NC3=CC=C(Br)C=C3F)C2=C1
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1

Thermo Scientific Chemicals Vandetanib

CAS: 443913-73-3 Fórmula molecular: C22H24BrFN4O2 Peso molecular (g/mol): 475.36 Clave InChI: UHTHHESEBZOYNR-UHFFFAOYSA-N Nombre IUPAC: N-(4-bromo-2-fluorofenil)-6-metoxi-7-[(1-metilpiperidin-4-il)metoxi]quinazolin-4-amina SMILES: COC1=C(OCC2CCN(C)CC2)C=C2N=CN=C(NC3=CC=C(Br)C=C3F)C2=C1

Clave InChI UHTHHESEBZOYNR-UHFFFAOYSA-N
Fórmula molecular C22H24BrFN4O2
CAS 443913-73-3
Peso molecular (g/mol) 475.36
SMILES COC1=C(OCC2CCN(C)CC2)C=C2N=CN=C(NC3=CC=C(Br)C=C3F)C2=C1
Nombre IUPAC N-(4-bromo-2-fluorofenil)-6-metoxi-7-[(1-metilpiperidin-4-il)metoxi]quinazolin-4-amina
2

Vandetanib, TRC

CAS: 443913-73-3 Fórmula molecular: C22 H24 Br F N4 O2 Peso molecular (g/mol): 475.35 Sinónimo: 4-Quinazolinamine, N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methyl-4-piperidinyl)methoxy]-,N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-[(1-methyl-4-piperidinyl)methoxy]-4-quinazolinamine,4-(4-Bromo-2-fluoroanilino)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazoline,CH 331,Caprelsa,N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-(N-methylpiperidin-4-ylmethoxy)quinazolin-4-amine,N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-amine,Vandetanib,ZD 6474,Zactima Nombre IUPAC: N-(4-bromo-2-fluorofenil)-6-metoxi-7-[(1-metilpiperidin-4-il)metoxi]quinazolin-4-amina SMILES: COc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OCC4CCN(C)CC4

Sinónimo 4-Quinazolinamine, N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methyl-4-piperidinyl)methoxy]-,N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-[(1-methyl-4-piperidinyl)methoxy]-4-quinazolinamine,4-(4-Bromo-2-fluoroanilino)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazoline,CH 331,Caprelsa,N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-(N-methylpiperidin-4-ylmethoxy)quinazolin-4-amine,N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-amine,Vandetanib,ZD 6474,Zactima
Fórmula molecular C22 H24 Br F N4 O2
CAS 443913-73-3
Peso molecular (g/mol) 475.35
SMILES COc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OCC4CCN(C)CC4
Nombre IUPAC N-(4-bromo-2-fluorofenil)-6-metoxi-7-[(1-metilpiperidin-4-il)metoxi]quinazolin-4-amina
3

Tocris Bioscience™ Vandetanib
GREENER_CHOICE

Potent VEGFR-2 inhibitor, also inhibits EGFR and RET oncoproteins activity

Fórmula molecular C22H24BrFN4O2
CAS 443913-73-3
Nombre del producto químico o material N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-[(1-methyl-4-piperidinyl)methoxy]-4-quinazolinamine
Almacenamiento recomendado Almacene a -20 °C.
Pureza 0.98
Objetivo VEGF Receptor Inhibitors
4

STEMCELL Technologies Vandetanib

Tyrosine kinase inhibitor; Inhibits VEGFR1, KDR, FLT-4, EGFR, FGFR, ABL, RET, and SRC

ENCOMPASS_PREFERRED
Fórmula molecular C22H24BrFN4O2
CAS 443913-73-3
Pureza ≥98%
5

Vandetanib, MedChemExpress

MedChemExpress Vandetanib (D6474) is a potent, orally active inhibitor of VEGFR2/KDR tyrosine kinase activity (IC50=40 nM). Vandetanib also has activity versus the tyrosine kinase activity of VEGFR3/FLT4 (IC50=110 nM) and EGFR/HER1 (IC50=500 nM).

ENCOMPASS_PREFERRED
Sinónimo ZD6474
Información de solubilidad DMSO : 27.5 mg/mL (57.85 mM; Need ultrasonic and warming)
Forma física Powder
Almacenamiento recomendado Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Peligro para la salud 1 H302∣H315∣H319∣H335
Color Blanco
SMILES FC1=CC(Br)=CC=C1NC2=NC=NC3=CC(OCC4CCN(CC4)C)=C(C=C23)OC
Notas de grado de pureza Research
Duración de almacenamiento Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Formula Weight (peso de la fórmula) 475.35
Fórmula molecular C22H24BrFN4O2
CAS 443913-73-3
Nombre del producto químico o material Vandetanib
Porcentaje de pureza 95.0%
Peso molecular (g/mol) 475.35
Grado Research
Para utilizar con (aplicación) Cancer-Kinase/protease