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Gibco™ Human GDNF Recombinant Protein, PeproTech®

Código de producto. 17874173 Tienda Gibco Productos
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Cantidad:
100 μg
10 μg
1 mg
250 μg
2 μg
500 μg
50 μg
Tamaño de la unidad:
1 miligramo
10 microgramos
100 microgramos
2 microgramos
250 microgramos
50 microgramos
500 microgramos
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Código de producto. Cantidad Tamaño de la unidad
17874173 10 μg 10 microgramos
17814073 100 μg 100 microgramos
17894713 1 mg 1 miligramo
17814463 250 μg 250 microgramos
17824723 2 μg 2 microgramos
17874643 500 μg 500 microgramos
17874303 50 μg 50 microgramos
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Código de producto. 17874173 Proveedor Gibco™ N.º de proveedor 4501010UG
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Description

Recombinant Protein

The functional human GDNF ligand is a disulfide-linked homodimer consisting of two 15 kDa polypeptide chains called monomers. Each monomer contains seven conserved cysteine residues, including Cys-101, which is used for inter-chain disulfide bridging, and others that are involved in the intramolecular ring formation known as the cysteine-knot configuration. The calculated molecular weight of Recombinant Human GDNF is 30.4 kDa. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

GDNF is a glycosylated, disulfide-bonded homodimer molecule. It was first discovered as a potent survival factor for midbrain dopaminergic neurons and was then shown to rescue these neurons in animal models of Parkinson's disease. GDNF is about 100 times more efficient survival factor for spinal motor neurons than the neurotrophins. GDNF is a neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake.
TRUSTED_SUSTAINABILITY

Spécification

Número de acceso P39905
Para utilizar con (aplicación) Bioactivity, Control, Western Blot Control
Formulación Protein with no preservative
ID de gen (Entrez) 2668
Peso molecular 30.4 kDa
Nombre Human GDNF
Método de purificación Purified
Cantidad 10 μg
Fuente E. coli
Requisitos de almacenamiento -20°C
Estado normativo RUO
Concentración de endotoxinas <1 EU/μg
Alias de gen AI385739; Astrocyte-derived trophic factor; ATF; ATF1; ATF2; Gdnf; glial cell derived neurotrophic factor; glial cell line derived neurotrophic factor; Glial cell line derived neutrophic factor; glial cell line-derived neurotrophic factor; gndf; HFB1-GDNF; hGDNF; H-GDNF; HSCR3; mGDNF; neurotrophic factor
Nombre común GDNF
Símbolo de gen GDNF
Actividad biológica Determined by a cell proliferation assay using SH-SY5Y cells. The expected ED50 for this effect is 1.0-10.0 ng/ml
Tipo de producto Protein
Conjugado Unconjugated
Recombinante Recombinant
Secuencia MSPDKQMAVL PRRERNRQAA AANPENSRGK GRRGQRGKNR GCVLTAIHLN VTDLGLGYET KEELIFRYCS GSCDAAETTY DKILKNLSRN RRLVSDKVGQ ACCRPIAFDD DLSFLDDNLV YHILRKHSAK RCGCI
Contenido y almacenamiento -20°C
Actividad Determined by a cell proliferation assay using SH-SY5Y cells. The expected ED50 for this effect is 1.0-10.0 ng/ml.
Sistema de expresión E. coli
Formulario Lyophilized
Grado de pureza o calidad ≥ 98% by SDS-PAGE gel and HPLC analyses.
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