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CH3O(S)CH3(S)CH3(S)OH(R)CH3CH3OH3COO(R)(S)H3C(R)OH(S)H3C(R)HO(R)OH(S)CH3(R)OH3CCH3(E)(E)(E)(Z)

CAS RN 88899-55-2

IUPAC Nombre: (3Z,5E,7R,8S,9S,11E,13E,15S,16R)-16-[(2S,3R,4S)-4-[(2R,4R,5S,6R)-2,4-dihydroxy-5-methyl-6-(propan-2-yl)oxan-2-yl]-3-hydroxypentan-2-yl]-8-hydroxy-3,15-dimethoxy-5,7,9,11-tetramethyl-1-oxacyclohexadeca-3,5,11,13-tetraen-2-one
Sinónimos: bafilomycin A1 bafilomycin
Peso molecular (g/mol): 622.84
Fórmula molecular: C35H58O9
InChi Key: XDHNQDDQEHDUTM-JQWOJBOSSA-N
SMILES: CO[C@H]1\C=C\C=C(C)\C[C@H](C)[C@H](O)[C@H](C)\C=C(/C)\C=C(OC)\C(=O)O[C@@H]1[C@@H](C)[C@@H](O)[C@H](C)[C@@]1(O)C[C@@H](O)[C@H](C)[C@H](O1)C(C)C
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4

Melford Bafilomicina A1

La bafilomicina A1 es un inhibidor potente y selectivo de la H+-ATPasa de tipo vacuolar (V-ATPasa), una enzima responsable de mantener el pH ácido en compartimentos celulares como los lisosomas y los endosomas.

5

Bafilomicina A1, TRC

CAS: 88899-55-2 Fórmula molecular: C35H58O9 Peso molecular (g/mol): 622.83 Sinónimo: 21-O-De(3-carboxy-1-oxo-2-propenyl)-2-demethyl-2-methoxy-24-methyl-hygrolidin Oxacyclohexadecane, hygrolidin deriv.,(-)-Bafilomycin A1,NSC 381866,[7R-[3Z,5E,7R*,8S*,9S*,11E,13E,15S*,16R*[1S*,2R*,3S*(2R*,4R*,5S*,6R*)]]]-8-Hydroxy-16-[2-hydroxy-1-methyl-3-[tetrahydro-2,4-dihydroxy-5-methyl-6-(1-methylethyl)-2H-pyran-2-yl]butyl]-3,15-dimethoxy-5,7,9,11-tetramethyl-oxacyclohexadeca-3,5,11,13-tetraen-2-one Nombre IUPAC: (3Z,5E,7R,8S,9S,11E,13E,15S,16R)-16-[(2S,3R,4S)-4-[(2R,4R,5S,6R)-2,4-dihidroxi-5-metil-6-propano-2-yloxano-2-il]-3-hidroxipentano-2-il]-8-hidroxi-3,15-dimetoxi-5,7,9,11-tetrametil-1-oxciclohexadeca-3,5,11,13-tetraen-2-one SMILES: OCC(=O)[C@@H](O)[C@@H](O)[C@@H](C)O

Sinónimo 21-O-De(3-carboxy-1-oxo-2-propenyl)-2-demethyl-2-methoxy-24-methyl-hygrolidin Oxacyclohexadecane, hygrolidin deriv.,(-)-Bafilomycin A1,NSC 381866,[7R-[3Z,5E,7R*,8S*,9S*,11E,13E,15S*,16R*[1S*,2R*,3S*(2R*,4R*,5S*,6R*)]]]-8-Hydroxy-16-[2-hydroxy-1-methyl-3-[tetrahydro-2,4-dihydroxy-5-methyl-6-(1-methylethyl)-2H-pyran-2-yl]butyl]-3,15-dimethoxy-5,7,9,11-tetramethyl-oxacyclohexadeca-3,5,11,13-tetraen-2-one
Fórmula molecular C35H58O9
CAS 88899-55-2
Peso molecular (g/mol) 622.83
SMILES OCC(=O)[C@@H](O)[C@@H](O)[C@@H](C)O
Nombre IUPAC (3Z,5E,7R,8S,9S,11E,13E,15S,16R)-16-[(2S,3R,4S)-4-[(2R,4R,5S,6R)-2,4-dihidroxi-5-metil-6-propano-2-yloxano-2-il]-3-hidroxipentano-2-il]-8-hidroxi-3,15-dimetoxi-5,7,9,11-tetrametil-1-oxciclohexadeca-3,5,11,13-tetraen-2-one
6

Bafilomycin A1, MedChemExpress

MedChemExpress Bafilomycin A1 (BafA1) is a specific and reversible inhibitor of vacuolar H+-ATPase (V-ATPase) with IC50 values of 4-400 nmol/mg. Bafilomycin A1, a macrolide antibiotic, is also used as an autophagy inhibitor at the late stage. Bafilomycin A1 blocks autophagosome-lysosome fusion and inhibits acidification and protein degradation in lysosomes of cultured cells. Bafilomycin A1 induces apoptosis.

ENCOMPASS_PREFERRED
7

STEMCELL Technologies Bafilomycin A1

Inhibits autophagy and vacuolar H+-ATPase (V-ATPase)

ENCOMPASS_PREFERRED