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Invitrogen™ Human ULK1, GST Tag Recombinant Protein

Código de producto. 15431234
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Cantidad:
10 μg
Unit Size:
10 microgramos
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15431234 10 μg 10 microgramos
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Product Code. 15431234 Supplier Invitrogen™ Supplier No. PV6430

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Description

Recombinant Protein

For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 μg, 10 μg and 20 μg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 μL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase. Recombinant human ULK1 (1-649) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. Validated in LanthaScreen™ Kinase Binding Assay Protocols available for simple use and optimized performance Multiple pack sizes available for convenient use Related Product:LanthaScreen™ Eu Kinase Binding Assay Protein Form: Recombinant, Fragment Assay Entry: Biochemical binding/kinetic The gene accession number for ULK1 is NP_003556.1.

ULK1 is a serine/threonine protein kinase that plays critical role during initial stages of autophagy which is a vital response to nutrient starvation. The conserved C-terminal domain (CTD) of ULK1 controls the regulatory function and localization of the protein. Knockdown of ULK1 inhibits the autophagic response as well as inhibiting rapamycin-induced autophagy consistent with a role downstream of mTOR. ULK1 forms a complex with FIP200 and ATG13 and this complex is essential for starvation-induced autophagy. Both FIP200 and ATG13 are critical for correct localization of ULK1 to the pre-autophagosome and stability of ULK1 protein. ULK1 is phosphorylated by the mTOR pathway in a nutrient starvation-regulated manner.
TRUSTED_SUSTAINABILITY

Specifications

Número de acceso O75385
Concentración See Label
Para utilizar con (aplicación) Kinase Assay
Formulación 50mM tris HCl with 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF, 10mM glutathione, 25% glycerol, 150mM NaCl and no preservative; pH 7.5
ID de gen (Entrez) 8408
Peso molecular 96.1 kDa
Nombre Human ULK1, GST Tag
Intervalo de pH 7.5
Método de purificación Purified
Cantidad 10 μg
Requisitos de almacenamiento -80°C, Avoid Freeze/Thaw Cycles
Estado normativo RUO
Alias de gen APG1; ATG 1; ATG1; ATG1 autophagy related 1 homolog; ATG1A; AU041434; Autophagy-related protein 1 homolog; C. elegans; EC:2.7.11.1; FLJ38455; hATG1; KIAA0722; mKIAA0722; Serine/threonine-protein kinase ULK1; serine/threonine-protein kinase Unc51.1; ULK 1; Ulk1; UNC 51; UNC51; unc-51 like autophagy activating kinase 1; unc-51 like kinase 1; Unc51.1; unc-51-like kinase 1
Nombre común ULK1
Símbolo de gen ULK1
Longitud de la proteína 1-649
Tipo de producto Protein
Conjugado Unconjugated
Especie Human
Recombinante Recombinant
Etiqueta de proteína GST-tag
Secuencia 1-649
Contenido y almacenamiento -80°C, Avoid Freeze/Thaw Cycles
Entrada del ensayo Biochemical binding/kinetic
Grupo de cinasas Serine/Threonine Kinase
Entrada diana ULK1
Sistema de expresión Baculovirus
Familia de proteínas Kinases & Inhibitors
Forma de proteína Recombinant, Fragment
Formulario Liquid
Subtipo de proteína Serine/Threonine Kinases
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