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Eurofins DiscoverX PAK2 Protein, Active
Descripción
p21-activated kinases (PAK) are serine/threonine kinases, which consist of the three highly homologous members PAK1 to -3, regulated by the GTPases Rac1 and Cdc42. PAKs are numerous and include morphogenetic regulation, modulation of signaling cascades leading to transcriptional regulation, and regulation of apoptotic pathways. PAK2 (PAK65) can monophosphorylate the myosin II regulatory light chain and induce retraction of permeabilized endothelial cells. PAK2 also can be activated by caspase-cleavage in addition to p21-binding. PAK2 inhibitors may have therapeutic potential in cancer treatment.
GenBank NM_U24153. The recombinant protein contains the amino acid substitutions L150F, P225T, V383I and (A339 with respect to this accession number. L150F, P225T and (A339 are reported inGenBank NM_U25975. The residue co ordinates in the native sequence have been given.
Especificaciones
Especificaciones
| Formulación | mg/mL of enzyme in 50 mM Tris/HCl pH 7.5, 150 mM NaCl, 0.1 mM EGTA, 0.03% Brij-35, 270 mM sucrose, 1 mM benzamidine, 0.2 mM PMSF, 0.1% 2-mercaptoethanol. Frozen solution. |
| Peso molecular | 62.8 kDa |
| Cantidad | 10 μg |
| Especie | Human |
| Recombinante | Recombinant |
| Etiqueta de proteína | N-terminal andC -terminal 6His-tagged and N-terminal T7 tagged |
| Sistema de expresión | Recombinant enzyme expressed in E. coli cells |
| Forma de proteína | Truncated |
| Grado de pureza o calidad | ≥56% |
| Expresión | PAK2, active |
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