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STEMCELL Technologies Human Recombinant IL-12

Interleukin 12

Marca:  STEMCELL Technologies 78027.1

Detalles adicionales : Peso : 0.00110kg

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Código de producto. 17199381

  • 163.59€ / 5 microgramos
Fecha estimada de envío: 21-12-2022
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  • Interleukin 12 (IL-12p70) is a heterodimeric cytokine composed of p35 and p40 subunits
  • IL-12 is produced by monocytes, macrophages, dendritic cells, neutrophils, and B cells in response to bacterial products and cytokines such as IFN-γ
  • The IL-12 receptor is expressed on T, NK, and dendritic cells
  • Upon binding, IL-12 initiates signaling via the JAK/STAT signaling pathway and stimulates NK, B, and T cells to produce IFN-γ (Watford et al.) It also regulates cytokine synthesis, proliferation of T and NK cells, and stimulates differentiation of CD4+ and CD8+ T cells (Germann & Rüde)
  • Mice that are deficient in IL-12 are susceptible to many intracellular pathogens and have impaired IFN-γ secretion, Th1 differentiation, and NK cytolytic activity; however, Th2 development and IL-4 production are enhanced (Watford et al.)


CTL maturation factor, Cytotoxic lymphocyte maturation factor, IL-12p70, Interleukin-12, Natural killer cell stimulatory factor, NKSF
5 μg
B Cells; Hematopoietic Stem and Progenitor Cells; Lymphocytes; NK Cells; T Cells
Ofertas especiales

Ofertas especiales