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Gibco™ Human MIP-1 beta (CCL4) Recombinant Protein, PeproTech®

Código de producto. 17820533
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50 μg
Tamaño de la unidad:
1 miligramo
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500 microgramos
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Código de producto. Cantidad unitSize
17820533 2 μg 2 microgramos
17801703 100 μg 100 microgramos
17811623 10 μg 10 microgramos
17840343 1 mg 1 miligramo
17840353 250 μg 250 microgramos
17891203 500 μg 500 microgramos
17851893 50 μg 50 microgramos
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Código de producto. 17820533 Proveedor Gibco™ N.º de proveedor 300092UG

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Descripción

Recombinant Protein

Recombinant Human MIP-1beta is a 7.6 kDa protein containing 69 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

CCL4 (macrophage inflammatory protein 1-beta, MIP1B) belongs to the intercrine beta (chemokine CC) family. Functionally, CCL4 is involved in chemotactic and proinflammatory effects, and homeostasis. CCL4 is produced by macrophages upon stimulation by bacterial endotoxins. CCL4 recruits and stimulates various inflammatory cells at sites of inflammation. CCL4 is produced by lymphocytes, macrophages and dendritic cells. Both CCL4 and the related protein CCL3 participate in the host response to invading bacterial, viral, parasite and fungal pathogens by regulating the trafficking and activation state of selected subgroups of inflammatory cells. While both CCL4 and CCL3 exert similar effects on monocytes, their effect on lymphocytes differ, with CCL4 selectively attracting CD4+ lymphocytes and CCL3 selectively attracting CD8+ lymphocytes. Additionally, both have been shown to be potent chemoattractants for B cells, eosinophils and dendritic cells. The processed form of CCL4 can induce down-modulation of surface expression of the chemokine receptor CCR5, thus inhibiting the CCR5-mediated entry of HIV-1 in T cells. CCL4 binds with high affinity to CCR5 receptors.
TRUSTED_SUSTAINABILITY

Especificaciones

Número de acceso P13236
Para utilizar con (aplicación) Control, Western Blot Control, ELISA Standard, Bioactivity
Formulación Protein with no preservative
ID de gen (Entrez) 6351
Peso molecular 7.6 kDa
Nombre Human MIP-1 beta (CCL4)
Método de purificación Purified
Cantidad 2 μg
Fuente E. coli
Requisitos de almacenamiento -20°C
Estado normativo RUO
Concentración de endotoxinas <1 EU/μg
Alias de gen ACT2; ACT-2; AT744.1; CC chemokine ligand 4; C-C motif chemokine 4; C-C motif chemokine ligand 4; Ccl4; chemokine (C-C motif) ligand 4; G-26; G-26 T-lymphocyte-secreted protein; HC21; immune activation gene 2; immune activation gene-2; immune activation protein 2; LAG1; LAG-1; Lymphocyte activation gene 1 protein; macrophage inflammatory protein 1-beta; macrophage inflammatory protein-1 beta; MGC104418; MGC126025; MGC126026; MIP-1 beta; MIP1b; MIP-1B; Mip1-b; MIP1B1; MIP1beta; MIP-1BETA; MIP-1-beta; MIP1-beta; MIP-1-beta(1-69); MIP-1-beta(3-69); PAT 744; Protein H400; putative MIP-1beta protein; RP23-320E6.8; SCY4A; SCYA2; Scya4; secreted protein G-26; SIS-gamma; small inducible cytokine A4; small inducible cytokine A4 (homologous to mouse Mip-1b); small-inducible cytokine A4; T-cell activation protein 2
Nombre común CCL4
Símbolo de gen CCL4
Actividad biológica Determined by its ability to chemoattract human blood monocytes using a concentration range of 5.0-20.0 ng/ml
Tipo de producto Protein
Conjugado Unconjugated
Recombinante Recombinant
Secuencia APMGSDPPTA CCFSYTARKL PHNFVVDYYE TSSLCSQPAV VFQTKRGKQV CADPSESWVQ EYVYDLELN
Contenido y almacenamiento -20°C
Actividad Determined by its ability to chemoattract human blood monocytes using a concentration range of 5.0-20.0 ng/ml.
Sistema de expresión E. coli
Formulario Lyophilized
Grado de pureza o calidad ≥ 98% by SDS-PAGE gel and HPLC analyses.
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