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Gibco™ Human LIF, Animal-Free Recombinant Protein, PeproTech®

Código de producto. 17816508
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Cantidad:
250 μg
5 μg
Tamaño de la unidad:
250 microgramos
5 microgramos
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Código de producto. Cantidad unitSize
17816508 5 μg 5 microgramos
17896478 250 μg 250 microgramos
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Código de producto. 17816508 Proveedor Gibco™ N.º de proveedor AF300055UG

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Descripción

Recombinant Protein

Recombinant Human LIF is a 19.7 kDa protein containing 180 amino acid residues, including three disulfide bonds. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

Leukemia inhibitory factor (LIF) is a 20 kDa protein that belongs to the IL-6 receptor family. It binds to a heterodimeric membrane receptor made up of a LIF-specific subunit, gp190 or LIFR, and the subunit gp130, which is shared with the other members of the IL-6 family. LIF expression has been observed in various tissues including thymus, lung, and neuronal tissue. LIF can be up-regulated by pro-inflammatory cytokines such as TNFα and IL-17, and elevated levels of LIF have been found in cases of rheumatoid arthritis, neural injury, systemic inflammation, and tuberculosis. LIF displays diverse biological effects, but is best known for its ability to inhibit the differentiation of embryonic stem cells in mice and contribute to stem cell self-renewal.Human and mouse LIF share 79% sequence homology and exhibit cross-species activity. However, LIF inhibition of stem cell differentiation appears to be mouse-specific.
TRUSTED_SUSTAINABILITY

Especificaciones

Número de acceso P15018
Para utilizar con (aplicación) Functional Assay
Formato Lyophilized
Formulación protein with no preservative
ID de gen (Entrez) 3976
Peso molecular 19.6 kDa
Nombre Human LIF, Animal-Free
Método de purificación HPLC, SDS-PAGE
Cantidad 5 μg
Estado normativo RUO
Concentración de endotoxinas <0.1 EU/ μg
Alias de gen CDF; cholinergic differentiation factor; cholinergic neuronal differentiation factor; d factor; DIA; differentiation inhibitory activity; differentiation-inducing factor; differentiation-stimulating factor; Emfilermin; hepatocyte-stimulating factor III; HILDA; human interleukin in DA cells; leukemia inhibitory factor; leukemia inhibitory factor (cholinergic differentiation factor); LIF; Melanoma-derived LPL inhibitor; MLPLI; myeloid leukaemia inhibitory factor
Nombre común LIF
Símbolo de gen Lif
Actividad biológica Determined by its ability to stimulate the proliferation of human TF-1 cells. The expected ED50 is ≤ 0.1 ng/ml, corresponding to a specific activity of ≥ 1 x 10^7 units/mg
Tipo de producto Protein
Conjugado Unconjugated
Recombinante Recombinant
Secuencia SPLPITPVNA TCAIRHPCHN NLMNQIRSQL AQLNGSANAL FILYYTAQGE PFPNNLDKLC GPNVTDFPPF HANGTEKAKL VELYRIVVYL GTSLGNITRD QKILNPSALS LHSKLNATAD ILRGLLSNVL CRLCSKYHVG HVDVTYGPDT SGKDVFQKKK LGCQLLGKYK QIIAVLAQAF
Contenido y almacenamiento -20°C
Actividad Determined by its ability to stimulate the proliferation of human TF-1 cells. The expected ED50 is ≤ 0.1 ng/ml, corresponding to a specific activity of ≥ 1 x 10^7 units/mg
Sistema de expresión E. coli
Formulario Lyophilized
Grado de pureza o calidad ≥ 98% by SDS-PAGE gel and HPLC analyses.
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