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Invitrogen™ Human LAG-3 (CD223) Fc Chimera Recombinant Protein
Descripción
It is recommended that the protein be aliquoted for optimal storage. It is recommended that sterile water (330 μL) be added to the vial to prepare a stock solution of 0.15 mg/mL. Concentration is measured by UV.
LAG-3 is a 70-kDa surface glycoprotein in the immunoglobulin superfamily, with structural homology to CD4. It binds to MHC class II molecules with higher affinity than CD4 and is involved in the negative regulation of T cell activation and homeostatic proliferation. LAG-3 is expressed on the surface of activated T cells, including regulatory T cells, and NK cells. Notably, CD8+ T cells express LAG-3 at significantly higher levels than CD4+ T cells. Additionally, the coexpression of LAG-3 and CD49b has been proposed as a marker for identifying Type 1 regulatory T cells (Tr1 cells) in both humans and mice. This highlights LAG-3s role in immune regulation and its potential as a target for therapeutic interventions in immune-related conditions.
Especificaciones
Especificaciones
| Número de acceso | P18627 |
| Para utilizar con (aplicación) | Binding Assay, Control, ELISA Standard |
| Formato | Lyophilized |
| Formulación | PBS with 15% trehalose and no preservative; pH 7.4 |
| ID de gen (Entrez) | 3902 |
| Peso molecular | 72.58 kDa |
| Nombre | Human LAG-3 (CD223) Fc Chimera |
| Intervalo de pH | 7.4 |
| Método de purificación | Purified |
| Cantidad | 500 μg |
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Título del producto
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