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Invitrogen™ Human ICAM-1 (CD54) Recombinant Protein
Descripción
This product contains purified recombinant human ICAM-1 protein with an N-terminal hexahistidine tag. This product may be used as a positive control in many immunological assays.
ICAM-1 (CD54) is an 85-110 kDa single-chain type 1 integral membrane glycoprotein with an extracellular domain of five immunoglobulin superfamily repeats, a transmembrane region and a cytoplasmic domain. ICAM-1 has 7 potential N-linked glycosylation sites and shares considerable amino acid sequence homology with ICAM-3 (CD50) and ICAM-2 (CD102). ICAM-1 binds to integrins of type CD11a/CD18 (leukocyte adhesion molecule, LFA-1), or CD11b/CD18 (Mac-1) and is exploited by Rhinovirus as a receptor. ICAM-1 is expressed by activated endothelial cells and detected on epithelial cells, fibroblasts, chondrocytes, B lymphocytes, T lymphocytes (low), monocytes, macrophages, dendritic cells and neutrophils, with lower levels that increase upon inflammation. ICAM-1 is also detected in some carcinoma and melanoma cells. Soluble ICAM-1 is detectable in the plasma and is elevated in patients with various inflammatory syndromes.
Especificaciones
Especificaciones
| Número de acceso | P05362 |
| Concentración | 1 mg/mL |
| Para utilizar con (aplicación) | Control, Western Blot |
| Formulación | 0.02 M tris HCl with 50% glycerol and no preservative; pH 8 |
| ID de gen (Entrez) | 3383 |
| Nombre | Human ICAM-1 (CD54) |
| Cantidad | 1 mg |
| Fuente | E. coli |
| Inmunógeno | N/A |
| Estado normativo | RUO |
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Título del producto
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