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Gibco™ Human Heat Stable FGF-basic (FGF-2/bFGF) (154 aa) Recombinant Protein, PeproTech®

Código de producto. 17867078
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Cantidad:
100 μg
10 μg
1 mg
250 μg
500 μg
50 μg
Tamaño de la unidad:
1 miligramo
10 microgramos
100 microgramos
250 microgramos
50 microgramos
500 microgramos
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Código de producto. Cantidad unitSize
17867078 50 μg 50 microgramos
17866798 1 mg 1 miligramo
17806868 100 μg 100 microgramos
17867058 500 μg 500 microgramos
17876798 10 μg 10 microgramos
17806978 250 μg 250 microgramos
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Código de producto. 17867078 Proveedor Gibco™ N.º de proveedor 10018BHS50UG

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280.00 EUR hasta el 2026-06-30
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Descripción

Recombinant Protein

FGF-basic loses its activity over time in solution at physiological temperatures and needs to be re-supplemented periodically to maintain its performance. As a result of selected amino acid substitutions, Heat Stable FGF-basic retains full biological activity and also maintains full activity over extended periods of time in solution at 370 C. These properties make Heat Stable FGF-basic a superior choice for use in cell culture media applications. Recombinant Heat Stable FGF-basic is a 17.2 kDa protein containing 154 amino acids. Human FGF-basic (FGF-2/bFGF) (154 aa), Recombinant Protein PeproTech® was developed under a license from Enantis. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

FGF2 (FGFb, fibroblast growth factor basic) belongs to the fibroblast growth factor (FGF) family, and interacts with high-affinity transmembrane receptors to influence cell proliferation and tissue neovascularization. FGF2 exists as five isoforms with distinct intracellular localizations and functions. The 18 kDa isoform is predominantly cytosolic and acts through cell surface receptors, whereas the 22, 22.5, 24 and 34 kDa isoforms are nuclear and may signal independent of transmembrane receptor pathways. In humans, the gene is located on the q arm of chromosome 4. FGF2 has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for FGF2 contains multiple polyadenylation sites, and is alternatively translated from non-AUG and AUG initiation codons, resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF. Diseases associated with FGF2 dysfunction include Kaposi Sarcoma and corneal neovascularization.
TRUSTED_SUSTAINABILITY

Especificaciones

Número de acceso P09038
Para utilizar con (aplicación) Functional Assay
Formato Lyophilized
Formulación protein with no preservative
ID de gen (Entrez) 2247
Peso molecular 17.2 kDa
Nombre Human Heat Stable FGF-basic (FGF-2/bFGF) (154 aa)
Método de purificación HPLC, SDS-PAGE
Cantidad 50 μg
Estado normativo RUO
Concentración de endotoxinas <1 EU/ μg
Alias de gen Basic fibroblast growth factor; basic fibroblast growth factor bFGF; bFGF; FGF; fgf basic; Fgf2; Fgf-2; Fgfb; FGF-b; Fibroblast growth factor; fibroblast growth factor 2; fibroblast growth factor 2 (basic); HBGF-2; Heparin-binding growth factor 2; H-FGF-b-147; H-FGF-b-154; M-FGF-b; Prostatic growth factor; prostatropin
Nombre común FGF2
Símbolo de gen FGF2
Actividad biológica Determined by a cell proliferation assay using Balb/c 3t3 cells. The expected ED50 range is 0.05-0.25 ng/ml
Tipo de producto Protein
Conjugado Unconjugated
Recombinante Recombinant
Secuencia Thermostable variant of human FGF-basic (154 amino acids) with proprietary amino acid substitutions.
Contenido y almacenamiento -20°C
Actividad Determined by a cell proliferation assay using Balb/c 3t3 cells. The expected ED50 range is 0.05-0.25 ng/ml
Sistema de expresión E. coli
Formulario Lyophilized
Grado de pureza o calidad ≥ 95% by SDS-PAGE gel and HPLC analyses.
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