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Gibco™ Human Heat Stable bFGF Recombinant Protein

Código de producto. 15940877
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Cantidad:
100 μg
500 μg
50 μg
5 μg
Unit Size:
100 microgramos
5 microgramos
50 microgramos
500 microgramos
Product Code. Cantidad unitSize
15940877 50 μg 50 microgramos
16443569 500 μg 500 microgramos
15930547 5 μg 5 microgramos
15950877 100 μg 100 microgramos
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Product Code. 15940877

Brand: Gibco™ PHG0368

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Description

Recombinant Protein

Carrier-Free Reconstitution: Centrifuge the vial briefly, before opening to bring the contents to the bottom. Reconstitute the lyophilized protein in sterile, distilled water to a concentration of 1.0 mg/mL. Alternatively, reconstitute at lower concentrations in carrier-containing medium. Do not vortex. Apportion the reconstituted protein into working aliquots and store at -20°C. Make any further dilutions of the reconstituted protein in medium, or buffered solution containing carrier protein, such as PBS with 0.1% BSA. For the 5 μg unit size, reconstitute directly in carrier-containing medium. For other unit sizes, reconstitute to 1.0 mg/mL as follows: 50 μg, reconstitute in 50 μL 100 μg, reconstitute in 100 μL 500 μg, reconstitute in 500 μL Storage: Store the lyophilized protein at -20°C, preferably desiccated. Upon reconstitution, apportion into working aliquots and store at -20°C (not in a frost-free freezer) for up to 12 months. Avoid repeated freeze-thaw cycles.

FGF2 (FGFb, fibroblast growth factor basic) belongs to the fibroblast growth factor (FGF) family, and interacts with high-affinity transmembrane receptors to influence cell proliferation and tissue neovascularization. FGF2 exists as five isoforms with distinct intracellular localizations and functions. The 18 kDa isoform is predominantly cytosolic and acts through cell surface receptors, whereas the 22, 22.5, 24 and 34 kDa isoforms are nuclear and may signal independent of transmembrane receptor pathways. In humans, the gene is located on the q arm of chromosome 4. FGF2 has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for FGF2 contains multiple polyadenylation sites, and is alternatively translated from non-AUG and AUG initiation codons, resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF. Diseases associated with FGF2 dysfunction include Kaposi Sarcoma and corneal neovascularization.
TRUSTED_SUSTAINABILITY

Specifications

Número de acceso P09038
Para utilizar con (aplicación) Bioactivity
Formulación 20mM potassium phosphate with 750mM NaCl and no preservative
ID de gen (Entrez) 2247
Peso molecular 19 kDa
Nombre Human Heat Stable bFGF
Método de purificación Purified
Cantidad 50 μg
Requisitos de almacenamiento -20°C
Estado normativo RUO
Concentración de endotoxinas <1 EU/μg
Alias de gen Basic fibroblast growth factor; basic fibroblast growth factor bFGF; bFGF; FGF; fgf basic; Fgf2; Fgf-2; Fgfb; FGF-b; Fibroblast growth factor; fibroblast growth factor 2; fibroblast growth factor 2 (basic); Fibroblast growth factor basic; HBGF-2; Heparin-binding growth factor 2; H-FGF-b-147; H-FGF-b-154; M-FGF-b; Prostatic growth factor; prostatropin
Nombre común FGF2
Símbolo de gen FGF2
Longitud de la proteína 155 aa + 20 aa for N-terminal tag for purification purposes
Actividad biológica ED50 = 0.6 - 1.1 ng/mL; determined by the dose-dependent proliferation of mouse NIH/3T3 fibroblast cells.
Tipo de producto Protein
Conjugado Unconjugated
Especie Human
Recombinante Recombinant
Esterilidad Sterile
Secuencia 155 aa + 20 aa for N-terminal tag for purification purposes
Contenido y almacenamiento -20°C
Clasificación Carrier-Free
Actividad ED50 = 0.6 - 1.1 ng/mL; determined by the dose-dependent proliferation of mouse NIH/3T3 fibroblast cells.
Nivel de endotoxinas <1 EU/μg
Condiciones de envío Approved for shipment on Wet or Dry Ice
Sistema de expresión E. coli
Familia de proteínas Growth Factors and Receptors
Formulario Lyophilized
Categoría de investigación Neurobiology, Oncology, Stem Cell Research, Microbiology, Differentiation, Angiogenesis
Grado de pureza o calidad >95% by SDS-PAGE
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