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Gibco™ Human Gremlin-1 Recombinant Protein, PeproTech®

Código de producto. 17891543
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Cantidad:
100 μg
10 μg
2 x 500 μg
250 μg
500 μg
50 μg
Tamaño de la unidad:
1 miligramo
10 microgramos
100 microgramos
250 microgramos
50 microgramos
500 microgramos
paquete de 2
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Código de producto. 17891543

Marca: Gibco™ 12042100UG

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Recombinant Protein

120-42-1MG will be provided as 2 x 500 μg (120-42-500UG). Recombinant Human Gremlin-1 is a 18.3 kDa protein containing 160 amino acid residues. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

In Xenopus, Gremlin belongs to a novel gene family that act as BMP antagonists in embryonic explants. The human homolog of Drm/Gremlin (CKTFS1B1) is localized on human chromosome 15q13--> q15. DRM-specific mRNA is expressed in different human tissues, including brain, ovary, intestine and colon. It has been suggested that down-regulation of DRM is associated with tumor progression, and support the hypothesis that human DRM may play an important role during both neuroembryological development and carcinogenesis.
TRUSTED_SUSTAINABILITY

Especificaciones

Número de acceso O60565
Para utilizar con (aplicación) Control, Bioactivity
Formulación Protein with no preservative
ID de gen (Entrez) 26585
Peso molecular 18.3 kDa
Nombre Human Gremlin-1
Método de purificación Purified
Cantidad 100 μg
Fuente CHO cells
Requisitos de almacenamiento -20°C
Estado normativo RUO
Concentración de endotoxinas <1 EU/μg
Alias de gen C15DUPq; Cell proliferation-inducing gene 2 protein; CKTSF1B1; colorectal adenoma and carcinoma 1; CRAC1; CRCS4; Cysteine knot superfamily 1, BMP antagonist 1; DAN domain family member 2; DAND2; Down-regulated in Mos-transformed cells protein; down-regulated in v-mos-transformed cells; Drm; DUP15q; Grem; GREM1; gremlin; gremlin 1; gremlin 1 homolog, cysteine knot superfamily; gremlin 1, cysteine knot superfamily, homolog; gremlin 1, DAN family BMP antagonist; gremlin 1-like protein; gremlin-1; HMPS; HMPS1; IHG-2; Increased in high glucose protein 2; increased in high glucose-2; ld; MPSH; PIG2
Nombre común GREM1
Símbolo de gen Grem1
Actividad biológica Determined by its ability to inhibit BMP-4 induced alkaline phosphatase production by ATDC-5 chondrogenic cells. The ED50 for this effect is 0.07-0.11 ug/ml
Tipo de producto Protein
Conjugado Unconjugated
Recombinante Recombinant
Secuencia KKKGSQGAIP PPDKAQHNDS EQTQSPQQPG SRNRGRGQGR GTAMPGEEVL ESSQEALHVT ERKYLKRDWC KTQPLKQTIH EEGCNSRTII NRFCYGQCNS FYIPRHIRKE EGSFQSCSFC KPKKFTTMMV TLNCPELQPP TKKKRVTRVK QCRCISIDLD
Contenido y almacenamiento -20°C
Actividad Determined by its ability to inhibit BMP-4 induced alkaline phosphatase production by ATDC-5 chondrogenic cells. The ED50 for this effect is 0.07-0.11 ug/ml.
Sistema de expresión CHO cells
Formulario Lyophilized
Grado de pureza o calidad ≥ 90% by SDS-PAGE gel and HPLC analyses.
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