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Gibco™ Human GM-CSF Recombinant Protein

Código de producto. 10150813
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Cantidad:
100 μg
10 μg
1 mg
Tamaño de la unidad:
cada uno
Código de producto. Cantidad unitSize
10150813 100 μg cada uno
10552045 1 mg cada uno
10797823 10 μg cada uno
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Código de producto. 10150813

Marca: Gibco™ PHC2011

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Descripción

Recombinant Protein

Carrier-Free Reconstitution: Centrifuge the vial briefly, before opening to bring the contents to the bottom. Reconstitute the lyophilized protein in sterile, distilled water to 0.1-1.0 mg/mL to regain full activity. Apportion the reconstituted protein into working aliquots and store at ≤-20°C. Make any further dilutions of the reconstituted protein in medium or buffered solution containing carrier protein, such as PBS with 0.1% BSA. Storage: Store the lyophilized protein at 2-8°C, preferably desiccated. Upon reconstitution, apportion into working aliquots and store at ≤-20°C (not in a frost-free freezer). Avoid repeated freeze-thaw cycles.

The GM-CSF gene encodes for a cytokine that regulates the production, differentiation, and function of macrophages and granulocytes. The active form of the protein exists as a homodimer in the extracellular space. This gene is located in a cluster of related genes at the chromosome region 5q31, which has been associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include interleukins 4, 5, and 13. The gene is involved in promoting tissue inflammation. Elevated levels of cytokines, including the one produced by this gene, have been observed in SARS-CoV-2 infected patients with acute respiratory distress syndrome. Mice that lack this gene or its receptor have been shown to develop pulmonary alveolar proteinosis.
TRUSTED_SUSTAINABILITY

Especificaciones

Número de acceso P04141
Para utilizar con (aplicación) Bioactivity
Formulación Protein with no preservative
ID de gen (Entrez) 1437
Peso molecular 14 kDa
Nombre Human GM-CSF
Método de purificación Purified
Cantidad 100 μg
Requisitos de almacenamiento 4°C
Estado normativo RUO
Concentración de endotoxinas <0.1 ng/μg
Alias de gen colony stimulating factor 2; colony stimulating factor 2 (granulocyte-macrophage); colony-stimulating factor; CSF; CSF2; Csfgm; cytokine; GMCSF; Gm-CSf; granulocyte macrophage colony stimulating factor; granulocyte macrophage-colony stimulating factor; granulocyte-macrophage colony stimulating factor 2; granulocyte-macrophage colony-stimulating factor; MGC131935; MGC138897; MGC151255; MGC151257; MGI-IGM; M-GM-CSF; molgramostin; put. GM-CSF; sargramostim
Nombre común GM-CSF
Símbolo de gen CSF2
Actividad biológica ED50 < 0.1 ng/mL; determined by the dose-dependent proliferation of human TF-1 cells.
Tipo de producto Protein
Conjugado Unconjugated
Especie Human
Recombinante Recombinant
Contenido y almacenamiento 4°C
Clasificación Carrier-Free
Actividad ED50 < 0.1 ng/mL; determined by the dose-dependent proliferation of human TF-1 cells.
Nivel de endotoxinas <0.1 ng/μg
Condiciones de envío Wet Ice
Sistema de expresión E. coli
Familia de proteínas Cytokines & Receptors
Forma de proteína Recombinant, Ligand
Formulario Lyophilized
Subtipo de proteína GM-CSF, G-CSF, & M-CSF
Categoría de investigación Signal Transduction, Oncology, Stem Cell Research, Differentiation, Drug Development
Línea de productos Gibco
Grado de pureza o calidad >95% by SDS-PAGE
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