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Gibco™ Human GDNF Recombinant Protein

Código de producto. 10679963
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Cantidad:
100 μg
10 μg
1 mg
5 μg
Tamaño de la unidad:
cada uno
Código de producto. Cantidad unitSize
10679963 10 μg cada uno
10641504 100 μg cada uno
10737683 1 mg cada uno
10110633 5 μg cada uno
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Código de producto. 10679963

Marca: Gibco™ PHC7045

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Description

Recombinant Protein

Carrier-Free Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute lyophilized human GDNF in sterile, distilled water to 0.1-0.5 mg/mL. These stock solutions should be apportioned into working aliquots and stored at ≤-20°C. Further dilution should be made in medium or buffered solution containing carrier protein, such as PBS with 0.1% BSA. Storage: Lyophilized human GDNF should be stored at 2°C to 8°C, preferably desiccated. Store reconstituted human GDNF at ≤-20°C (not in a frost-free freezer). Keep freeze-thaw cycles to a minimum.

GDNF is a glycosylated, disulfide-bonded homodimer molecule. It was first discovered as a potent survival factor for midbrain dopaminergic neurons and was then shown to rescue these neurons in animal models of Parkinson's disease. GDNF is about 100 times more efficient survival factor for spinal motor neurons than the neurotrophins. GDNF is a neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake.
TRUSTED_SUSTAINABILITY

Specifications

Número de acceso P39905
Para utilizar con (aplicación) Bioactivity
Formulación Protein with no preservative
ID de gen (Entrez) 2668
Peso molecular 30.1 kDa
Nombre Human GDNF
Método de purificación Purified
Cantidad 10 μg
Requisitos de almacenamiento 4°C
Estado normativo RUO
Concentración de endotoxinas <0.1 ng/μg
Alias de gen AI385739; Astrocyte-derived trophic factor; ATF; ATF1; ATF2; Gdnf; glial cell derived neurotrophic factor; glial cell line derived neurotrophic factor; Glial cell line derived neutrophic factor; glial cell line-derived neurotrophic factor; gndf; HFB1-GDNF; hGDNF; H-GDNF; HSCR3; mGDNF; neurotrophic factor
Nombre común GDNF
Símbolo de gen GDNF
Actividad biológica ED50 ≤ 10 n/mL; determined by the dose-dependent neurite outgrowth of PC-12 cells in the presence of soluble GFR-alpha.
Tipo de producto Protein
Conjugado Unconjugated
Especie Human
Recombinante Recombinant
Secuencia SPDKQMAVLP RRERNRQAAA ANPENSRGKG RRGQRGKNRG CVLTAIHLNV TDLGLGYETK EELIFRYCSG SCDAAETTYD KILKNLSRNR RLVSDKVGQA CCRPIAFDDD LSFLDDNLVY HILRKHSAKR CGCI
Contenido y almacenamiento 4°C
Clasificación Carrier-Free
Actividad ED50 ≤ 10 n/mL; determined by the dose-dependent neurite outgrowth of PC-12 cells in the presence of soluble GFR-alpha.
Nivel de endotoxinas <0.1 ng/μg
Condiciones de envío Approved for shipment on Wet or Dry Ice
Sistema de expresión E. coli
Familia de proteínas Growth Factors & Receptors
Forma de proteína Recombinant, Ligand
Formulario Lyophilized
Subtipo de proteína Neurotrophic Factors
Categoría de investigación Neurobiology, Stem Cell Research, Differentiation
Línea de productos Gibco
Grado de pureza o calidad >98% by SDS-PAGE
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