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Gibco™ Human GDF-5, Animal-Free Recombinant Protein, PeproTech®
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Cantidad:
250 μg
50 μg
Tamaño de la unidad:
250 microgramos
50 microgramos
Descripción
Recombinant Human GDF-5 (BMP-14/CDMP-1) is a 27.0 kDa homodimeric disulfide-linked protein consisting of two 120 amino acid polypeptide chains. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis
GDF-5 is expressed in long bones during embryonic development and postnatally in articular cartilage. Mutations in the GDF-5 gene have been implicated in Hunter-Thompson type dwarfism and in Grebe Syndrome, which is characterized by short stature, extra digits, and short and deformed extremities. The mature and functional form of GDF-5 is a homodimer of two 120 amino-acid polypeptide chain (monomers) linked by a single disulfide bond. Each GDF-5 monomer is expressed as the C-terminal part of a precursor polypeptide, which also contains a 27 amino acid signal peptide and a 354 amino acid propeptide. This precursor undergoes intracellular dimerization, and upon secretion it is processed by a furin-type protease.
Especificaciones
Especificaciones
| Número de acceso | P43026 |
| Para utilizar con (aplicación) | Functional Assay |
| Formato | Lyophilized |
| Formulación | protein with no preservative |
| ID de gen (Entrez) | 8200 |
| Peso molecular | 27 kDa |
| Nombre | Human GDF-5, Animal-Free |
| Método de purificación | HPLC, SDS-PAGE |
| Cantidad | 50 μg |
| Estado normativo | RUO |
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