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Gibco™ Human EPO (Erythropoietin) Recombinant Protein

Código de producto. 10181193
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Cantidad:
500 UI
Tamaño de la unidad:
cada uno
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10181193 500 UI cada uno
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Código de producto. 10181193 Proveedor Gibco™ N.º de proveedor PHC2054

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Descripción

Recombinant Protein

Carrier-Free Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile, deionized water to a concentration of 12,000-120,000 IU/mL. Further dilutions can be made in aqueous buffers. For long term storage, EPO solutions should be supplemented with carrier protein, such as 0.1% HSA or BSA. Storage: This lyophilized preparation is stable at room temperature for three weeks, but should be stored desiccated below -18°C. Upon reconstitution, the preparation is stable for up to one week at 2°C to 8°C, but should be stored below -18°C for long term storage. Avoid repeated freeze/thaw cycles.

Erythropoietin (EPO) protein is a growth factor essential for the survival, proliferation, and differentiation of erythroid precursors. EPO is not responsible for early commitment to the lineage, and instead induces the final maturation of partially differentiated erythroid cells and the production of red cell-specific proteins, such as hemoglobin. The EPO receptor (EPOR) is present in higher levels on precursor cells, and expression diminishes with cell maturation.Hepatocytes are the main source of EPO in the fetus, followed by interstitial cells of the kidney after birth and through adulthood. EPO expression is upregulated during hypoxia, and low levels of transcription have also been detected in lung and brain tissue under these conditions. Recent data suggest that EPO may also play a role in the protection of neuronal tissue from damage and initiation of repair.
TRUSTED_SUSTAINABILITY

Especificaciones

Número de acceso P01588
Para utilizar con (aplicación) Bioactivity
Formulación 0.006mg citric acid, 0.59mg sodium citrate with 0.58mg NaCl and no preservative
ID de gen (Entrez) 2056
Peso molecular 30.4 kDa
Nombre Human EPO (Erythropoietin)
Método de purificación Purified
Cantidad 500 UI
Requisitos de almacenamiento -20°C
Estado normativo RUO
Concentración de endotoxinas <0.1 ng/μg
Alias de gen EP; EPO; Epoetin; erythropoietin; MGC138142; MVCD2
Nombre común Epo
Símbolo de gen EPO
Actividad biológica Specific Activity = 150,000 IU/mg; determined by measuring normocythaemic mice.
Tipo de producto Protein
Conjugado Unconjugated
Especie Human
Recombinante Recombinant
Secuencia APPRLICDSR VLERYLLEAK EAENITTGCA EHCSLNENIT VPDTKVNFYA WKRMEVGQQA VEVWQGLALL SEAVLRGQAL LVNSSQPWEP LQLHVDKAVS GLRSLTTLLR ALGAQKEAIS PPDAASAAPL RTITADTFRK LFRVYSNFLR GKLKLYTGEA CRTGDR
Contenido y almacenamiento -20°C
Clasificación Carrier-Free
Actividad Specific Activity = 150,000 IU/mg; determined by measuring normocythaemic mice.
Nivel de endotoxinas <0.1 ng/μg
Condiciones de envío Approved for shipment on Wet or Dry Ice
Sistema de expresión CHO cells
Familia de proteínas Growth Factors & Receptors
Forma de proteína Recombinant, Ligand
Formulario Lyophilized
Subtipo de proteína EPO
Categoría de investigación Neurobiology, Stem Cell Research, Differentiation
Línea de productos Gibco
Grado de pureza o calidad >98% by SDS-PAGE
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