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Gibco™ Human Amphiregulin Recombinant Protein, PeproTech®
Descripción
Recombinant Human Amphiregulin is an 11.3 kDa glycoprotein consisting of 98 amino acid residues. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis
Amphiregulin (AR) binds to EGF-Receptor (EGFR) with lower affinity than EGF. The mature secreted form AR is an 84-amino acid residue glycosylated polypeptide growth regulator, which is generated by proteolytic processing of a 252-amino acid transmembrane precursor. Seven different polypeptide ligands, which derive from distinct genes, are capable of binding to the extracellular domain of EGFR. These ligands include EGF, TGFalpha, AR, HB-EGF, cripto-1, epiregulin, and betacellulin. All of these growth factors contain a characteristic EGF-like domain which is defined by 6 evenly spaced cysteine residues that generate 3 loops through the formation of disulfide bonds. AR protein has been localized by immunohistochemistry to the epithelium of the colon, stomach, pancreas, breast, and placenta. AR is reportedly overexpressed in human cancers of breast, colon, stomach, and pancreas.
Especificaciones
Especificaciones
| Número de acceso | P15514 |
| Para utilizar con (aplicación) | ELISA, Functional Assay, Western Blot |
| Formulación | protein with no preservative |
| ID de gen (Entrez) | 374 |
| Peso molecular | 11.3 kDa |
| Nombre | Human Amphiregulin |
| Cantidad | 100 μg |
| Fuente | E. coli |
| Estado normativo | RUO |
| Concentración de endotoxinas | <1 EU/ μg |
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Título del producto
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