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Gibco™ Human Amphiregulin Recombinant Protein, PeproTech®

Código de producto. 17820563
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Cantidad:
100 μg
10 μg
1 mg
250 μg
500 μg
50 μg
Tamaño de la unidad:
1 miligramo
10 microgramos
100 microgramos
250 microgramos
50 microgramos
500 microgramos
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Código de producto. Cantidad unitSize
17820563 1 mg 1 miligramo
17830103 100 μg 100 microgramos
17810183 10 μg 10 microgramos
17849892 250 μg 250 microgramos
17801253 500 μg 500 microgramos
17880763 50 μg 50 microgramos
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Código de producto. 17820563 Proveedor Gibco™ N.º de proveedor 10055B1MG

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Descrizione

Recombinant Protein

Recombinant Human Amphiregulin is an 11.3 kDa glycoprotein consisting of 98 amino acid residues. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

Amphiregulin (AR) binds to EGF-Receptor (EGFR) with lower affinity than EGF. The mature secreted form AR is an 84-amino acid residue glycosylated polypeptide growth regulator, which is generated by proteolytic processing of a 252-amino acid transmembrane precursor. Seven different polypeptide ligands, which derive from distinct genes, are capable of binding to the extracellular domain of EGFR. These ligands include EGF, TGFalpha, AR, HB-EGF, cripto-1, epiregulin, and betacellulin. All of these growth factors contain a characteristic EGF-like domain which is defined by 6 evenly spaced cysteine residues that generate 3 loops through the formation of disulfide bonds. AR protein has been localized by immunohistochemistry to the epithelium of the colon, stomach, pancreas, breast, and placenta. AR is reportedly overexpressed in human cancers of breast, colon, stomach, and pancreas.
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Specifica

Número de acceso P15514
Para utilizar con (aplicación) ELISA, Functional Assay, Western Blot
Formulación protein with no preservative
ID de gen (Entrez) 374
Peso molecular 11.3 kDa
Nombre Human Amphiregulin
Cantidad 1 mg
Fuente E. coli
Estado normativo RUO
Concentración de endotoxinas <1 EU/ μg
Alias de gen amphiregulin; amphiregulin B; AR; AREG; AREGB; colorectum cell-derived growth factor; CRDGF; Mcub; MGC13647; schwannoma-derived growth factor; SDGF
Nombre común Amphiregulin
Símbolo de gen AREG
Actividad biológica Determined by its ability to stimulate the proliferation of mouse Balb/c 3T3 cells. The expected ED50 for this effect is 5-10 ng/ml
Conjugado Unconjugated
Recombinante Recombinant
Secuencia SVRVEQVVKP PQNKTESENT SDKPKRKKKG GKNGKNRRNR KKKNPCNAEF QNFCIHGECK YIEHLEAVTC KCQQEYFGER CGEKSMKTHS MIDSSLSK
Contenido y almacenamiento -20°C
Sistema de expresión E. coli
Formulario Lyophilized
Grado de pureza o calidad ≥ 95% by SDS-PAGE gel and HPLC analyses.
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