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Description
- Redesigned protein L ligand captures antibody Fabs, bispecifics, and other variants containing a kappa light chain with high binding capacity and improved alkaline stability
- High dynamic binding capacity for efficient capture of target molecules
- Stable when cleaned with 0.1 M NaOH, reducing risk for bioburden incidents
- Provides good resolution for product-related impurities in the capture of bispecific antibodies
As the diversity of antibody variants increases, so does the need for chromatography resins that can capture and purify these variants. As an alternative to protein A, protein L can be used to capture antibody Fabs, bispecific antibodies, and other molecules containing kappa variants of the variable light (VL) chain. Protein L binds human kappa light chain subtypes 1, 3, and 4 and mouse kappa light chain subtype 1.
Specifications
Specifications
| Volumen del lecho | 1 mL |
| Diámetro interior (imperial) | 0,3 in |
| Diámetro interior (métrico) | 7 mm |
| Cantidad | 1 x 1 mL |
| Altura (imperial) | 1 in. |
| Altura (métrico) | 25 mm |
| Caudal | <4 mL/min |
| Presión máxima | 5bar |
| Tipo de columna | Affinity Column |
| Para utilizar con (aplicación) | Cromatografía de afinidad de anticuerpos |
Safety and Handling
- HiTrap MabSelect VL, 1 x 1 ml
- Atención
- Líquido inflamable Categoría 3
- H226-Líquidos y vapores inflamables.
- P210-Mantener alejado del calor, de superficies calientes, de chispas, de llamas abiertas y de cualquier otra fuente de ignición. No fumar.
- P501b-Eliminar el contenido/el recipiente en conforme a la reglamentación local/regional/nacional/internacional.
- MIXTURE LIST-Contém: ethanol
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