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Fluconazole, 99%, Thermo Scientific™
Fluconazole, CAS # 86386-73-4, is a synthetic triazole with antifungal activity against some species of Candida. It also shows inhibitory activity against cytochrome P-450 enzymes and it is a demethylase.
Marca: Thermo Scientific Alfa Aesar J62015.03
| Cantidad | 1g |
|---|
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Description
This Thermo Scientific brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific.
General Description
• Fluconazole, 98% is a triazole compound showing antifungal activity mainly against Candida, Coccidioides, and Cryptococcus species
• It has been shown to inhibit fungal cytochrome P-450 sterol C-14 α-demethylation, resulting in the accumulation of fungal 14 α-methyl sterols, the loss of normal fungal sterols, and associated fungistatic activity
• It also inhibits cytochrome P450 family 2 subfamily c member 9 (CYP2C9)
• Mammalian cell demethylation is much less susceptible to fluconazole inhibition
Applications
• Fluconazole has fungistatic activity against many fungal strains including Candida albicans, Candida glabrata, Candida parapsilosis, Candida tropicalis, and Cryptococcus neoformans.
• Fluconazole interferes with fungal ergosterol synthesis and downregulates the metallothionein gene
• In biological experiments, this compound has been used to assess minimum inhibitory concentration in (MIC)-fungal assays
• It has also been used as a positive control in antifungal assay of plants
Identifiants chimiques
| 86386-73-4 | |
| 306.277 | |
| RFHAOTPXVQNOHP-UHFFFAOYSA-N | |
| 3365 | |
| 2-(2,4-difluorophenyl)-1,3-bis(1,2,4-triazol-1-yl)propan-2-ol |
| C13H12F2N6O | |
| MFCD00274549 | |
| fluconazole, diflucan, triflucan, elazor, biozolene, biocanol, fungata, fluconazol, fluconazolum, flucazol | |
| CHEBI:46081 | |
| C1=CC(=C(C=C1F)F)C(CN2C=NC=N2)(CN3C=NC=N3)O |
Spécification
| Fluconazole | |
| 1.05 | |
| MFCD00274549 | |
| 14,4122 | |
| Soluble indimethylsulfoxide and ethanol. | |
| C1=CC(=C(C=C1F)F)C(CN2C=NC=N2)(CN3C=NC=N3)O | |
| 306.277 | |
| CHEBI:46081 | |
| 99% |
| 86386-73-4 | |
| C13H12F2N6O | |
| 1g | |
| fluconazole, diflucan, triflucan, elazor, biozolene, biocanol, fungata, fluconazol, fluconazolum, flucazol | |
| RFHAOTPXVQNOHP-UHFFFAOYSA-N | |
| 2-(2,4-difluorophenyl)-1,3-bis(1,2,4-triazol-1-yl)propan-2-ol | |
| 3365 | |
| 306.27 |
Sécurité et traitement
Identifiant produit
Mention d'avertissement
Catégorie de danger
Mention de danger
Conseils de prudence
Informations supplémentaires
- Fluconazole
Mention d'avertissement
- Peligro
Catégorie de danger
- Toxicidad aguda Categoría 4
- Lesión ocular grave/irritación ocular Categoría 2
- Toxicidad para la reproducción Categoría 1B
- Corrosión o irritación cutáneas Categoría 2
- Toxicidad específica en determinados órganos tras una exposición única Categoría 2
Mention de danger
- H302-Nocivo en caso de ingestión.
- H315-Provoca irritación cutánea.
- H319-Provoca irritación ocular grave.
- H360D-Puede dañar al feto.
- H371-Puede provocar daños en los órganos.
Conseils de prudence
- P280-Llevar guantes/prendas/gafas/máscara de protección.
- P301+P330+P331-EN CASO DE INGESTIÓN: Enjuagarse la boca. NO provocar el vómito.
- P302+P352-EN CASO DE CONTACTO CON LA PIEL: Lavar con abundante agua/.
- P305+P351+P338-EN CASO DE CONTACTO CON LOS OJOS: Aclarar cuidadosamente con agua durante varios minutos. Quitar las lentes de contacto, si lleva y resulta fácil. Seguir aclarando.
- P312-Llamar a un CENTRO DE TOXICOLOG A/médico/si la persona se encuentra mal.
Informations supplémentaires
- MIXTURE LIST-Contain: Fluconazole
Nom du produit
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