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Crizotinib, MedChemExpress

Código de producto. 16494037
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Código de producto. Cantidad unitSize
16494037 50 mg 50 miligramos
16461926 500 mg 500 miligramos
16461326 200 mg 200 miligramos
16438128 10 mg 10 miligramos
16437886 100 mg 100 miligramos
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Código de producto. 16494037

Marca: Medchem Express HY50878

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Description

MedChemExpress Crizotinib (PF-02341066) is an orally bioavailable, ATP-competitive ALK and c-Met inhibitor with IC50s of 20 and 8 nM, respectively. Crizotinib inhibits tyrosine phosphorylation of NPM-ALK and tyrosine phosphorylation of c-Met with IC50s of 24 and 11 nM in cell-based assays, respectively. Crizotinib is also a ROS1 inhibitor. Crizotinib has effective tumor growth inhibition.

Crizotinib (PF-02341066) is an orally bioavailable, ATP-competitive ALK and c-Met inhibitor with IC50s of 20 and 8 nM, respectively. Crizotinib inhibits tyrosine phosphorylation of NPM-ALK and tyrosine phosphorylation of c-Met with IC50s of 24 and 11 nM in cell-based assays, respectively. Crizotinib is also a ROS1 inhibitor. Crizotinib has effective tumor growth inhibition.

Specifications

Nombre del producto químico o material Crizotinib
CAS 877399-52-5
Color Off-White
Notas de grado de pureza Research
Fórmula molecular C21H22Cl2FN5O
Cantidad 50 mg
Sinónimo PF-02341066
Información de solubilidad DMSO : 33.33 mg/mL (74.01 mM; Need ultrasonic) ∣H2O : < 0.1 mg/mL (ultrasonic) (insoluble)
SMILES ClC1=C(F)C=CC(Cl)=C1[C@H](OC2=CC(C3=CN(N=C3)C4CCNCC4)=CN=C2N)C
Peso molecular (g/mol) 450.34
Formula Weight (peso de la fórmula) 450.34
Porcentaje de pureza 97.05%
Grado Research
Forma física Powder
Para utilizar con (aplicación) Cancer-Kinase/protease
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Research purposes only

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