CAS RN 475108-18-0

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Tivozanib, TRC

CAS: 475108-18-0 Fórmula molecular: C22 H19 Cl N4 O5 Peso molecular (g/mol): 454.86 Sinónimo: Urea, N-[2-chloro-4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-N'-(5-methyl-3-isoxazolyl)-,N-[2-Chloro-4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-N'-(5-methyl-3-isoxazolyl)urea,AV 951,KRN 951,Kil 8951,N-[2-Chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl]-N'-(5-methyl-3-isoxazolyl)urea,Tivozanib Nombre IUPAC: 1-[2-cloro-4-(6,7-dimetoxiquinolina-4-il)oxifenilo]-3-(5-metil-1,2-oxazol-3-il)urea SMILES: COc1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)on4)c(Cl)c3)c2cc1OC

Precio y disponibilidad
Especificaciones

Sinónimo	Urea, N-[2-chloro-4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-N'-(5-methyl-3-isoxazolyl)-,N-[2-Chloro-4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-N'-(5-methyl-3-isoxazolyl)urea,AV 951,KRN 951,Kil 8951,N-[2-Chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl]-N'-(5-methyl-3-isoxazolyl)urea,Tivozanib
Fórmula molecular	C22 H19 Cl N4 O5
CAS	475108-18-0
Peso molecular (g/mol)	454.86
SMILES	COc1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)on4)c(Cl)c3)c2cc1OC
Nombre IUPAC	1-[2-cloro-4-(6,7-dimetoxiquinolina-4-il)oxifenilo]-3-(5-metil-1,2-oxazol-3-il)urea

Tivozanib, MedChemExpress

MedChemExpress Tivozanib (AV-951; KRN951) is a potent and selective and orally active VEGFR tyrosine kinase inhibitor with IC50是of 0.21, 0.16, 0.24 nM for VEGFR-1, VEGFR-2, VEGFR-3, respectively. Tivozanib inhibits angiogenesis and vascular permeability in tumor tissues and shows antitumor activity. Tivozanib has the potential for the research of metastatic renal cell carcinoma (RCC) .

Precio y disponibilidad
Especificaciones

Sinónimo	AV-951 KRN951
Información de solubilidad	DMSO : 25 mg/mL (54.96 mM; Need ultrasonic)
Forma física	Solid
Almacenamiento recomendado	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Color	Marrón
SMILES	O=C(NC1=CC=C(C=C1Cl)OC2=CC=NC3=CC(OC)=C(C=C23)OC)NC4=NOC(C)=C4
Notas de grado de pureza	Research
Duración de almacenamiento	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Formula Weight (peso de la fórmula)	454.86
Fórmula molecular	C₂₂H₁₉ClN₄O₅
CAS	475108-18-0
Nombre del producto químico o material	Tivozanib
Porcentaje de pureza	99.37%
Peso molecular (g/mol)	454.86
Grado	Research
Para utilizar con (aplicación)	Cancer-Kinase/protease

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