CAS RN 1373423-53-0
IUPAC Nombre:
ethyl 3-{[2-(pyridin-2-yl)-6-(2,3,4,5-tetrahydro-1H-3-benzazepin-3-yl)pyrimidin-4-yl]amino}propanoate
Sinónimos:
ethyl 3-{[2-(pyridin-2-yl)-6-(1,2,4,5-tetrahydro-3-benzazepin-3-yl)pyrimidin-4-yl]amino}propanoate
Peso molecular (g/mol):
417.51
Fórmula molecular:
C24H27N5O2
InChi Key:
WBKCKEHGXNWYMO-UHFFFAOYSA-N
SMILES:
CCOC(=O)CCNC1=NC(=NC(=C1)N1CCC2=CC=CC=C2CC1)C1=CC=CC=N1
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1
Tocris Bioscience™ GSK J4
CAS: 1373423-53-0 Fórmula molecular: C24H27N5O2
2
GSK-J4, MedChemExpress
MedChemExpress GSK-J4 is a potent dual inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A with IC50s of 8.6 and 6.6 μM, respectively. GSK-J4 inhibits LPS-induced TNF-α production in human primary macrophages with an IC50 of 9 μM. GSK J4 is a cell permeable prodrug of GSK-J1. GSK-J4 induces endoplasmic reticulum stress-related apoptosis.
