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Invitrogen™ Zap-70 Monoclonal Antibody (1E7.2), Alexa Fluor™ 488
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Código de producto. 10008502
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Cantidad:
500 μL
Tamaño de la unidad:
cada uno
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10008502 500 μL cada uno
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Código de producto. 10008502 Proveedor Invitrogen™ N.º de proveedor MHZAP7020

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Descripción

Mouse Monoclonal Antibody

Based on our testing, publications, and results reported from customers, the Alexa Fluor™ 488 dye provides the best fluorescein (FITC) substitute.

ZAP-70 is a cytosolic protein tyrosine kinase that is a member of the Syk family of proteins. ZAP-70 is expressed exclusively in T-cells and natural killer cells and is required for T-cell receptor activation. Upon T cell antigen receptor (TCR) engagement, ZAP70 is phosphorylated on tyrosines 292, 315 and 319 in the interdomain B, located between the SH2 and kinase domains. Phosphorylation of both tyrosines 315 (a Vav binding site) and 319 (a Lck binding site) enhances ZAP70 function in mediating lymphocyte signaling, while tyrosine 292 terminates the transient activation of ZAP70 and attentuates lymphocyte signaling.
TRUSTED_SUSTAINABILITY

Especificaciones

Antígeno Zap-70
Aplicaciones Flow Cytometry
Clasificación Monoclonal
Clon 1E7.2
Conjugado Alexa Fluor 488
Formulación PBS with 4mg/mL BSA and 0.1% sodium azide
génica ZAP70
N.º de referencia del gen P43403, P43404
Alias de gen 70 kDa zeta-associated protein; 70 kDa zeta-chain associated protein; ADMIO2; EC 2.7.10.2; FLJ17670; FLJ17679; I79_004087; IMD48; kinase ZAP70; mrtle; mur; Selective T cell defect; Srk; STCD; STD; syk-related protein tyrosine kinase; syk-related tyrosine kinase; Tyrosine-protein kinase ZAP-70; Tyrosine-protein kinase ZAP-70;TZK; TZK; ZA70; Zap70; ZAP-70; Zeta chain associated protein kinase 70kDa; zeta chain of T cell receptor associated protein kinase; zeta chain of T cell receptor associated protein kinase 70; zeta chain of T cell receptor associated protein kinase 70kDa; zeta-chain (TCR) associated protein kinase; zeta-chain (TCR) associated protein kinase 70; zeta-chain (TCR) associated protein kinase 70kDa; zeta-chain associated protein kinase 70kDa; zeta-chain associated protein kinase, 70kD
Símbolos de los genes ZAP70
Especie del huésped Mouse
Inmunógeno GST-fusion protein of Human ZAP70, amino acids 282-307.
Método de purificación Purified
Cantidad 500 μL
Estado normativo ASR
Primario o secundario Primary
ID de gen (Entrez) 22637, 7535
Especies diana Human, Mouse
Contenido y almacenamiento 4°C, store in dark
Tipo de producto Antibody
Formulario Liquid
Isotype IgG1
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