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Invitrogen™ Vinculin Recombinant Rabbit Monoclonal Antibody (42H89L44)

Código de producto. 15306934
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Cantidad:
100 μg
Tamaño de la unidad:
100 UG
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15306934 100 μg 100 UG
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Código de producto. 15306934 Proveedor Invitrogen™ N.º de proveedor 700062

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Descripción

Rabbit Recombinant Monoclonal Antibody

Intact IgG appears on a non-reducing gel as ~150 kDa band and upon reduction generating a ~25 kDa light chain band and a ~50 kDa heavy chain. This antibody reacts with Human Vinculin. Based on sequence similarity, reactivity to chimpanzee, Rhesus monkey, swine, equine, mouse, rat, bovine, and chicken is expected. Immunogen sequence IRGALAEARKIAELCDDPKERDDILRSLGEI SALTSKLADLRRQGKGDSPEARALAKQV ATALQNLQTKTNRAVANSRPAKAAVHLE GKIEQAQRWIDNPTVDDRGVGQAAIRGL VAEGHRLANVMMGPYRQDLLAKCDRVD QLTAQLADLAARGEGESPQARALASQLQ DSLKDLKARMQEAM. Test material for western blotting/immunofluorescence: HeLa cells. Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

Vinculin (VCL) is a cytoskeletal protein associated with cell-cell and cell-extracellular matrix adherens-type junctions. It functions as one of several interacting proteins involved in anchoring F-actin to the membrane. It has been shown that a sequence of molecular interactions might be involved in the transmembrane assembly of adhesion plaques. In the assembly of adhesion plaques, the beta subunit of integrin binds to talin. Talin binds to vinculin that interacts with alpha-actinin and possibly with itself. Since alpha-actinin binds to and cross-links actin filaments, vinculin represents a key element in the transmembrane linkage of the extracellular matrix to the cytoplasmic microfilament system. Mutations in the gene can result in cardiomyopathy dilated 1W or familial hypertrophic 15.
TRUSTED_SUSTAINABILITY

Especificaciones

Antígeno Vinculin
Aplicaciones Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry, Multiplex Immunohistochemistry
Clasificación Recombinant Monoclonal
Clon 42H89L44
Concentración 0.5 mg/mL
Conjugado Unconjugated
Formulación PBS with 0.09% sodium azide
génica VCL
N.º de referencia del gen P18206, Q64727
Alias de gen 9430097D22; AA571387; AI462105; AW545629; CMD1W; CMH15; epididymis luminal protein 114; HEL114; metavinculin; meta-vinculin; metavinculin {ECO:0000250; MV; MVCL; RP11-178G16.3; UniProtKB:P18206}; unnamed protein product; Vcl; vcl {ECO:0000250; VIN; vinc; vinc 1; VINC1; Vinculin; vinculin {ECO:0000250
Símbolos de los genes VCL
Especie del huésped Rabbit
Inmunógeno A recombinant protein corresponding to amino acids 408-591 of P18206.
Método de purificación Protein A
Cantidad 100 μg
Estado normativo RUO
Primario o secundario Primary
ID de gen (Entrez) 22330, 7414
Especies diana Human, Mouse
Contenido y almacenamiento Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Tipo de producto Antibody
Formulario Liquid
Isotype IgG
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