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Topotecan hydrochloride, Tocris Bioscience™

Código de producto. 18772544
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Cantidad:
10 mg
50 mg
Tamaño de la unidad:
10 miligramos
50 miligramos
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Código de producto. Cantidad unitSize
18772544 10 mg 10 miligramos
18742584 50 mg 50 miligramos
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Código de producto. 18772544 Proveedor Tocris Bioscience N.º de proveedor 4562/10

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Regulatorisk: Dette produkt falder ind under Lov om kemiske stoffer og produkter - lovbekendtgørelse nr. 1755 af 22. december 2006. Hvis det er relevant, skal kunden fremskaffe en licens før levering.

Beskrivelse

DNA topoisomerase I inhibitor; Camptothecin (Cat. No. 1100) analog

Topotecan hydrochloride is a DNA topoisomerase I inhibitor; induces rapid apoptotic death in human B-lineage acute lymphoblastic leukemia (ALL) cells. Improves survival in three mouse models of poor prognosis ALL; downregulates B-Myb and MycN expression in neuroblastoma cells. Water-soluble analog of Camptothecin (Cat. No. 1100). Orally bioavailable. Topotecan disrupts the interaction between NHP2L1 and U4 RNA by binding to U4 and inhibits RNA splicing.
TRUSTED_SUSTAINABILITY

Kemiske identifikatorer

CAS 119413-54-6
Fórmula molecular C23H23N3O5
Peso molecular (g/mol) 421.45
Número MDL MFCD28989044
Clave InChI UCFGDBYHRUNTLO-QHCPKHFHSA-N
Sinónimo topotecan hydrochloride, topotecan hcl, hycamptamine hydrochloride, topotecan monohydrochloride, unii-956s425zcy, topotecan hydrochloride usan, nogitecan hydrochloride, dsstox_cid_25952, dsstox_rid_81248
PubChem CID 60699
Nombre IUPAC (19S)-8-[(dimethylamino)methyl]-19-ethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.0²,¹¹.0⁴,⁹.0¹⁵,²⁰]henicosa-1(21),2,4,6,8,10,15(20)-heptaene-14,18-dione
SMILES CC[C@@]1(O)C(=O)OCC2=C1C=C1N(CC3=CC4=C(CN(C)C)C(O)=CC=C4N=C13)C2=O

Tekniske data

Nombre del producto químico o material Topotecan hydrochloride
Cantidad 10 mg
Formula Weight (peso de la fórmula) 457.91
Porcentaje de pureza >98%
Produkttitel
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