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TAU Mouse anti-Human, Mouse, Porcine, Rat, Clone: 1E9A8, Proteintech
Mouse Monoclonal Antibody
140.00€ - 399.00€
Especificaciones
Antígeno | TAU |
---|---|
Clon | 1E9A8 |
Concentración | 1 mg/mL |
Aplicaciones | Western Blot, Immunohistochemistry (Paraffin) |
Clasificación | Monoclonal |
Código de producto | Marca | Cantidad | Precio | Cantidad y disponibilidad | |||||
---|---|---|---|---|---|---|---|---|---|
Código de producto | Marca | Cantidad | Precio | Cantidad y disponibilidad | |||||
16828435
|
Proteintech
66499-1-IG-20UL |
20 μL |
140.00€
20 microlitros |
Fecha estimada de envío: 13-05-2024 Inicie sesión para ver el stock |
Por favor, inicie sesión para comprar este producto. ¿No tiene usuario web? Regístrese hoy mismo. | ||||
16818435
|
Proteintech
66499-1-IG-150UL |
150 μL |
399.00€
150 microlitros |
Fecha estimada de envío: 13-05-2024 Inicie sesión para ver el stock |
Por favor, inicie sesión para comprar este producto. ¿No tiene usuario web? Regístrese hoy mismo. | ||||
Descripción
Tau is a neuronal microtubule-associated protein found predomitly on axons. The function of Tau is to promote tubulin polymerization and stabilize microtubules. The C-terminus binds axonal microtubules while the N- terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton while the longer isoforms may preferentially play a role in its stabilization. In its hyper-phosphorylated form, Tau is the major component of paired helical filaments (PHF), the building block of neurofibrillary lesions in Alzheimer′s diseases (AD) brain. Hyper-phosphorylation impairs the microtubule binding function of Tau, resulting in the destabilization of microtubules in AD brains, ultimately leading to the degeneration of the affected neurons. Numerous serine/threonine kinases phosphorylate Tau, including GSK-3beta, protein kinase A (PKA), cyclindependent kinase 5 (cdk5) and casein kinase II. Hyper-phosphorylated Tau is found in neurofibrillary lesions in a range and other central nervous system disorders such as Pick′s disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy.Especificaciones
TAU | |
1 mg/mL | |
Monoclonal | |
Liquid | |
RUO | |
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3 | |
DDPAC, FTDP 17, MAPT, MAPTL, MSTD, MTBT1, MTBT2, Neurofibrillary tangle protein, Paired helical filament tau, PHF tau, PPND, TAU | |
Mapt | |
IgG2c | |
Protein A | |
Antibody |
1E9A8 | |
Western Blot, Immunohistochemistry (Paraffin) | |
Unconjugated | |
Mouse | |
Human, Mouse, Rat, Porcine | |
P10636, P10637, P19332 | |
100738351, 17762, 29477, 4137 | |
TAU Fusion Protein Ag21926 | |
Primary | |
-20°C | |
MAPT |