Learn More
Thermo Scientific Chemicals Tacrolimus, 99+%
Descripción
Interacts with the immunophilins cyclophilin and FKBP-12.Tacrolimus is used as an immunosuppressive drug that blocks T cell proliferation in vitro. Further, it is used as a research tool in chemically induced dimerization applications.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General Description
• Tacrolimus is a macrolide isolated from Streptomyces tsukubaensis, that shows immunosuppressant, neuroprotective, and neuroregenerative activities, having the ability to block T-cell proliferation and activation in response to antigenic or mitogenic stimulation
• Tacrolimus interacts with the immunophilins cyclophilin and FKBP-12. Tacrolimus binds to the FKBP-12 protein (FK506 binding protein) and forms a complex with calcium-dependent proteins. This FKBP12-FK506 complex inhibits calcineurin phosphatase activity, resulting in decreased cytokine production, inhibition of T-lymphocyte signal transduction
• Tacrolimus also inhibits the transcription for genes that encode IL-3, IL-4, IL-5, GM-CSF, and TNF, all of which are involved in the early stages of T-cell activation
• This compound can also inhibit the release of pre-formed mediators from skin mast cells and basophils and downregulate the expression of FceRI on Langerhans cells
Application
• Tacrolimus has been studied in vitro to understand its impact on neutrophil production and/or survival • It is applied to suppress the inflammation in ulcerative cells
• It is used as a research tool in chemically induced dimerization applications in biology
• It has been used in in vitro studies to investigate its effect on human monocyte-derived dentritic cells
•
Especificaciones
Especificaciones
| Cantidad | 50 mg |
| Descripción | Blanco a blanquecino |
| Contenido y almacenamiento | De - 30 °C a - 10 °C |
| Formato | Powder |
| Para utilizar con (aplicación) | Interacts with the immunophilins cyclophilin and FKBP-12 |
| ensayo | ≥99% |
| Formula Weight (peso de la fórmula) | 804.02g/mol |
| Punto de fusión | 120°C to 125°C |
| Solubilidad | Freely soluble in DMSO or ethanol; Poorly soluble in water |
| Tipo de producto | Signal Transduction Reagent |
| Mostrar más |
Seguridad y manipulación
- Tacrolimus
- Peligro
- Toxicidad aguda Categoría 3
- H301-Tóxico en caso de ingestión.
- P264-Lavarse concienzudamente tras la manipulación.
- P301+P310-EN CASO DE INGESTIÓN: Llamar inmediatamente a un CENTRO DE TOXICOLOG A/médico/.
- MIXTURE LIST-Contain: Tacrolimus
RUO – Research Use Only
Al hacer clic en Enviar, acepta que Fisher Scientific se ponga en contacto con usted en relación con los comentarios que ha proporcionado en este formulario. No compartiremos su información para ningún otro fin. Toda la información de contacto proporcionada se mantendrá de acuerdo con nuestra Política de Privacidad. Política de privacidad.