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Invitrogen™ SOCS1 Polyclonal Antibody
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Código de producto. 12838392
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Cantidad:
100 μg
Tamaño de la unidad:
100 microgramos
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12838392 100 μg 100 microgramos
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Código de producto. 12838392 Proveedor Invitrogen™ N.º de proveedor PA520229

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Rabbit Polyclonal Antibody

A suggested positive control is human spleen tissue lysate. PA5-20229 can be used with blocking peptide PEP-0342.

The Suppressor of cytokine signaling (SOCS) and cytokine-inducible SH2 proteins are a family of intracellular proteins which regulate the immune cell responses to cytokines. SOCS1 acts to suppress dendritic cell (DC) as well as T cell hyperactivation following cytokine signaling by inhibiting JAK tyrosine kinase, a kinase necessary for type I and II cytokine receptors to initiate signaling, by directly binding to the catalytic domain of the kinase. SOCS1 also possesses E3 ubiquitin protein ligase activity that results in the polyubiquitination of its target proteins and subsequent degradation by the proteosome. It is through this method that SOCS1 negatively regulates signaling by Toll-like receptors TLR2 and TLR4 by mediating the degradation of the TLR signaling adaptor protein TIRAP.
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Especificaciones

Antígeno SOCS1
Aplicaciones Western Blot
Clasificación Polyclonal
Concentración 1 mg/mL
Conjugado Unconjugated
Formulación PBS with 0.02% sodium azide
génica Socs1
N.º de referencia del gen O15524
Alias de gen CIS1; Cish1; Cish7; cytokine inducible SH2-containing protein 1; cytokine inducible SH2-containing protein 7; cytokine-inducible SH2 protein 1; JAB; JAK binding protein; JAK2-binding protein; JAK-binding protein; Socs1; SOCS-1; SSI1; SSI-1; STAT induced SH3 protein 1; STAT-induced STAT inhibitor 1; Suppressor of cytokine signaling 1; Tec-interacting protein 3; TIP3; TIP-3
Símbolos de los genes Socs1
Especie del huésped Rabbit
Inmunógeno A 17 amino acid peptide from near the amino terminus of human SOCS1.
Método de purificación Antigen Affinity Chromatography
Cantidad 100 μg
Estado normativo RUO
Primario o secundario Primary
ID de gen (Entrez) 8651
Especies diana Human
Contenido y almacenamiento Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Tipo de producto Antibody
Formulario Liquid
Isotype IgG
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